//www.koonmotors.com/news/mind_brain/parkinson's/ Information on Parkinson's disease. Learn about Parkinson's disease treatments, symptoms, new research and medication. en-us Sun, 10 Sep 2023 20:48:30 EDT Sun, 10 Sep 2023 20:48:30 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/mind_brain/parkinson's/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/09/230907130356.htm A new artificial intelligence tool can help people with Parkinson's disease remotely assess the severity of their symptoms within minutes. While expert neurologists performed slightly better than the AI model, the AI model outperformed the primary care physicians with UPDRS certification. Thu, 07 Sep 2023 13:03:56 EDT //www.koonmotors.com/releases/2023/09/230907130356.htm //www.koonmotors.com/releases/2023/08/230830151742.htm Researchers have developed a blood test that detects Parkinson's disease, potentially establishing a way to help diagnose the condition before nervous system damage worsens. A new blood-based diagnostic test would be a major advancement for Parkinson's disease, which afflicts 10 million people worldwide and is the second-most common neurodegenerative disease after Alzheimer's. Wed, 30 Aug 2023 15:17:42 EDT //www.koonmotors.com/releases/2023/08/230830151742.htm //www.koonmotors.com/releases/2023/08/230822151748.htm Many researchers believe that the neurodegenerative disorder gets started in the gut. Research now suggests that an autoimmune reaction may be driving those early events. Tue, 22 Aug 2023 15:17:48 EDT //www.koonmotors.com/releases/2023/08/230822151748.htm //www.koonmotors.com/releases/2023/08/230811115422.htm Identification of risk factors for Parkinson's disease (PD) is essential for early diagnosis. Dating back to the 1920s, Parkinson's disease and parkinsonism -- an umbrella term that refers to motor symptoms found in Parkinson's disease and also other conditions -- have long been described in boxers. Repetitive head impacts from tackle football can also have long-term neurological consequences like chronic traumatic encephalopathy (CTE). But research on the association between participation in tackle football and PD is limited. Fri, 11 Aug 2023 11:54:22 EDT //www.koonmotors.com/releases/2023/08/230811115422.htm //www.koonmotors.com/releases/2023/08/230809164716.htm In Parkinson's disease, growing evidence targets neuroinflammation as essential for brain pathogenesis. But which group of immune cells that reside in the brain direct this inflammatory response? Scientists used a mouse model of Parkinson's disease to show that border-associated macrophages -- not microglia -- mediate the neuroinflammatory response in the brain. Wed, 09 Aug 2023 16:47:16 EDT //www.koonmotors.com/releases/2023/08/230809164716.htm //www.koonmotors.com/releases/2023/08/230803113012.htm Although there is a long-standing, common assumption that most -- if not all -- dopamine neurons solely respond to rewards or reward-predicting cues, researchers instead discovered that one genetic subtype fires when the body moves and does not respond to rewards at all. The discovery could help explain why loss of dopamine neurons leads to Parkinson's disease. Thu, 03 Aug 2023 11:30:12 EDT //www.koonmotors.com/releases/2023/08/230803113012.htm //www.koonmotors.com/releases/2023/07/230727144133.htm A group of nerve cells in the brain has the remarkable ability to completely stop all forms of movement, a new mouse study shows. The discovery provides valuable insight into how the nervous system can control our movements. Thu, 27 Jul 2023 14:41:33 EDT //www.koonmotors.com/releases/2023/07/230727144133.htm //www.koonmotors.com/releases/2023/07/230719150009.htm A new discovery paves the way for clinical trials that use patients' own cells to treat Parkinson's disease. Wed, 19 Jul 2023 15:00:09 EDT //www.koonmotors.com/releases/2023/07/230719150009.htm //www.koonmotors.com/releases/2023/07/230719145938.htm Scientists have uncovered a new mechanism by which mutations in a gene parkin contribute to familial forms of Parkinson's disease. The discovery opens a new avenue for Parkinson's therapeutics, scientists report in a new study. They discovered that mutations in parkin result in a breakdown of contacts between two key workers in the cell -- lysosomes and mitochondria. Wed, 19 Jul 2023 14:59:38 EDT //www.koonmotors.com/releases/2023/07/230719145938.htm //www.koonmotors.com/releases/2023/07/230712124631.htm 研究人员表明,移植苏rgical procedure (called 'needle trauma') triggers a profound immune response and causes the death of most grafted dopamine neurons. They also found that co-transplantation of neuronal cell therapy with host regulatory T cells resulted in effective suppression of needle trauma and significant improvement in the survival and recovery of grafts. These findings suggest a path for the 'realistic' use of cell therapy to treat neurodegenerative disorders. Wed, 12 Jul 2023 12:46:31 EDT //www.koonmotors.com/releases/2023/07/230712124631.htm //www.koonmotors.com/releases/2023/06/230627225220.htm Researchers have solved a long-standing mystery about how a protein helps rid the body of damaged mitochondria, in findings that could help lead to potential new treatments for Parkinson's disease. Tue, 27 Jun 2023 22:52:20 EDT //www.koonmotors.com/releases/2023/06/230627225220.htm //www.koonmotors.com/releases/2023/05/230518120851.htm Through a novel pairing of epidemiology and toxicity screening, researchers were able to identify 10 pesticides that were directly toxic to key neurons. Thu, 18 May 2023 12:08:51 EDT //www.koonmotors.com/releases/2023/05/230518120851.htm //www.koonmotors.com/releases/2023/05/230516115542.htm Two years of heavy exposure to TCE, a liquid chemical that lingers in the air, water and soil, may increase the risk of Parkinson's disease by 70%. Tue, 16 May 2023 11:55:42 EDT //www.koonmotors.com/releases/2023/05/230516115542.htm //www.koonmotors.com/releases/2023/04/230412131051.htm Dopamine, a brain chemical long associated with pleasure, motivation and reward-seeking, also appears to play an important role in why exercise and other physical efforts feel 'easy' to some people and exhausting to others, according to results of a study of people with Parkinson's disease. Parkinson's disease is marked by a loss of dopamine-producing cells in the brain over time. Wed, 12 Apr 2023 13:10:51 EDT //www.koonmotors.com/releases/2023/04/230412131051.htm //www.koonmotors.com/releases/2023/03/230316114102.htm Researchers have found a new way to remove waste from the brain after hemorrhage. Thu, 16 Mar 2023 11:41:02 EDT //www.koonmotors.com/releases/2023/03/230316114102.htm //www.koonmotors.com/releases/2023/03/230303105344.htm 研究人员用来描述他们的results can be harnessed to discover potential new treatments for Parkinson's disease, according to a new study. The study employed an artificial intelligence (AI) system to identify an existing anti-cholesterol drug that has the ability to promote the disposal of mitochondria, energy-making components of the cell which are damaged in the disease. Fri, 03 Mar 2023 10:53:44 EST //www.koonmotors.com/releases/2023/03/230303105344.htm //www.koonmotors.com/releases/2023/02/230228205244.htm Researchers have identified gut bacteria that are associated with dementia with Lewy bodies. Changing the levels of three bacteria, Collinsella, Ruminococcus, and Bifidobacterium, may delay the onset and progression of this neurodegenerative disease. Tue, 28 Feb 2023 20:52:44 EST //www.koonmotors.com/releases/2023/02/230228205244.htm //www.koonmotors.com/releases/2023/01/230124103835.htm Researchers attempted to identify early symptoms of Parkinson's disease using voice data. In their study, the researchers used artificial intelligence (AI) to analyze and assess speech signals, where calculations are done and diagnoses made in seconds rather than hours. Tue, 24 Jan 2023 10:38:35 EST //www.koonmotors.com/releases/2023/01/230124103835.htm //www.koonmotors.com/releases/2022/11/221128101246.htm 研究人员发现,一组蛋白质different shapes in the spinal fluid of healthy individuals and Parkinson's patients. These could be used in the future as a new type of biomarker for this disease. Mon, 28 Nov 2022 10:12:46 EST //www.koonmotors.com/releases/2022/11/221128101246.htm //www.koonmotors.com/releases/2022/11/221110114303.htm A team has developed a new tool that can predict how Parkinson's disease patients will fare over the course of a year based on their genetics, brain scans and physical examinations. Thu, 10 Nov 2022 11:43:03 EST //www.koonmotors.com/releases/2022/11/221110114303.htm //www.koonmotors.com/releases/2022/11/221109124330.htm Researchers have discovered that the neurotransmitter adenosine effectively acts as a brake to dopamine, another well-known neurotransmitter involved in motor control. The discovery could immediately suggest new avenues of drug development to treat symptoms of Parkinson's disease, a movement disorder where the loss of dopamine-producing cells has been widely implicated as a cause. Wed, 09 Nov 2022 12:43:30 EST //www.koonmotors.com/releases/2022/11/221109124330.htm //www.koonmotors.com/releases/2022/11/221108120444.htm Parkinson's disease affects 3% of population over 65 years old, and the average age of onset is 60. Regarding juvenile Parkinson, which represents the rest of all Parkison's cases, the disease begins before 40 years old. Now, a group of researchers has deciphered the molecular mechanism by which a mutation of the adenosine type 1 receptor gene is associated with juvenile Parkinson's. Tue, 08 Nov 2022 12:04:44 EST //www.koonmotors.com/releases/2022/11/221108120444.htm //www.koonmotors.com/releases/2022/11/221103140754.htm 一个新的治疗神经和精神diseases, that works by reducing the excitability of overactive brain cells, has been developed. Thu, 03 Nov 2022 14:07:54 EDT //www.koonmotors.com/releases/2022/11/221103140754.htm //www.koonmotors.com/releases/2022/11/221101100735.htm Researchers have found that COVID-19 activates the same inflammatory response in the brain as Parkinson's disease. The discovery identified a potential future risk for neurodegenerative conditions in people who've had COVID-19, but also a possible treatment. Tue, 01 Nov 2022 10:07:35 EDT //www.koonmotors.com/releases/2022/11/221101100735.htm //www.koonmotors.com/releases/2022/10/221019172137.htm People who gain or lose weight soon after being diagnosed with Parkinson's disease may be more likely to have changes in their thinking skills than people who maintain their weight, according to a new study. Wed, 19 Oct 2022 17:21:37 EDT //www.koonmotors.com/releases/2022/10/221019172137.htm //www.koonmotors.com/releases/2022/10/221005111946.htm A new screening test app could help advance the early detection of Parkinson's disease and severe COVID-19, improving the management of these illnesses. Developed by a research team of engineers and neurologists, the test can produce accurate results using just people's voice recordings. Wed, 05 Oct 2022 11:19:46 EDT //www.koonmotors.com/releases/2022/10/221005111946.htm //www.koonmotors.com/releases/2022/09/220920154748.htm Aggregates of the protein alpha-synuclein spread in the brains of people with Parkinson's disease through a cellular waste-ejection process, suggests a new study. Tue, 20 Sep 2022 15:47:48 EDT //www.koonmotors.com/releases/2022/09/220920154748.htm //www.koonmotors.com/releases/2022/09/220912112423.htm Researchers have shown that a hormone secreted into the blood during endurance, or aerobic, exercise reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice. Mon, 12 Sep 2022 11:24:23 EDT //www.koonmotors.com/releases/2022/09/220912112423.htm //www.koonmotors.com/releases/2022/08/220830135635.htm Scientists have uncovered how a build-up of harmful protein starts to happen within neurons in Parkinson's disease, ultimately causing nerve cell death. By looking at how, where and why this build-up happens, the work provides unique insight into a key biological process driving Parkinson's. Tue, 30 Aug 2022 13:56:35 EDT //www.koonmotors.com/releases/2022/08/220830135635.htm //www.koonmotors.com/releases/2022/08/220829112912.htm Inactivation of a particular protein complex that plays a key role in keeping genes switched off leads to nerve cells not producing enough essential neurotransmitters. This could be part of the explanation for diseases such as Parkinson's as well as anxiety disorders. Mon, 29 Aug 2022 11:29:12 EDT //www.koonmotors.com/releases/2022/08/220829112912.htm //www.koonmotors.com/releases/2022/08/220825120322.htm A device with the appearance of a Wi-Fi router uses a neural network to discern the presence and severity of one of the fastest-growing neurological diseases in the world. Thu, 25 Aug 2022 12:03:22 EDT //www.koonmotors.com/releases/2022/08/220825120322.htm //www.koonmotors.com/releases/2022/07/220715151014.htm Cellular changes in Parkinson's could be revealed by adapting a related technique, known as quantitative MRI (qMRI). A new method enabled researchers to look at microstructures within the part of the deep brain known as the striatum -- an organ which is known to deteriorate during the progress of Parkinson's disease. With a novel method of analysis, biological changes in the cellar tissue of the striatum were clearly revealed and the team was able to demonstrate that these changes were associated with the early stages of Parkinson's and patients' movement dysfunction. Fri, 15 Jul 2022 15:10:14 EDT //www.koonmotors.com/releases/2022/07/220715151014.htm //www.koonmotors.com/releases/2022/07/220713152848.htm Researchers are a step closer to understanding how Parkinson's disease develops and progresses thanks to chemical biological tools. Wed, 13 Jul 2022 15:28:48 EDT //www.koonmotors.com/releases/2022/07/220713152848.htm //www.koonmotors.com/releases/2022/07/220707141904.htm Copper exposure in the environment and the protein alpha-synuclein in the human brain could play an important role in the pathogenesis of Parkinson's disease. Researchers were able to show how the protein takes on an unusual shape when exposed to large amounts of copper ions. The findings could help develop new strategies for the treatment of neurodegenerative diseases. Thu, 07 Jul 2022 14:19:04 EDT //www.koonmotors.com/releases/2022/07/220707141904.htm //www.koonmotors.com/releases/2022/06/220608112527.htm Neuroscientists identified three circuits in the thalamus that influence the development of motor and nonmotor symptoms of Parkinson's disease. And by manipulating these circuits, they could reverse Parkinson's symptoms in mice. Wed, 08 Jun 2022 11:25:27 EDT //www.koonmotors.com/releases/2022/06/220608112527.htm //www.koonmotors.com/releases/2022/06/220607194448.htm Older adults who start to experience bad dreams or nightmares could be exhibiting the earliest signs of Parkinson's disease, say researchers. Tue, 07 Jun 2022 19:44:48 EDT //www.koonmotors.com/releases/2022/06/220607194448.htm //www.koonmotors.com/releases/2022/05/220524110655.htm Emotion-recognition among people with disorders such as Parkinson's disease or schizophrenia may be affected by changes in the levels dopamine in the brain, say researchers. Tue, 24 May 2022 11:06:55 EDT //www.koonmotors.com/releases/2022/05/220524110655.htm //www.koonmotors.com/releases/2022/05/220519132735.htm In studies with mouse and human tissue, as well as live mice, researchers report that a snag in the normal process of cleaning up broken DNA in brain cells may hasten the progression of Parkinson's disease. Specifically, the researchers found that a protein dubbed 'STING' responds to clean-up signals in brain cells damaged by Parkinson's disease by creating a cycle of inflammation that may accelerate the disease's progression. Thu, 19 May 2022 13:27:35 EDT //www.koonmotors.com/releases/2022/05/220519132735.htm //www.koonmotors.com/releases/2022/05/220516213134.htm Ultra-powerful 7T MRI scanners could be used to help identify those patients with Parkinson's disease and similar conditions most likely to benefit from new treatments for previously-untreatable symptoms, say scientists. Mon, 16 May 2022 21:31:34 EDT //www.koonmotors.com/releases/2022/05/220516213134.htm //www.koonmotors.com/releases/2022/05/220516135013.htm Exercise increases levels of a chemical involved in brain cell growth, which bolsters the release of the 'feel good' hormone dopamine, a new study shows. Dopamine is known to play a key role in movement, motivation, and learning. Experts have long understood that regular running raises dopamine activity in the brain and may protect nerve cells from damage. In addition, past research has tied exercise-driven boosts in the dopamine-triggering chemical called brain-derived neurotrophic factor (BDNF) and in dopamine levels to improvements in learning and memory. However, the precise way these three factors interact has until now remained unclear. Mon, 16 May 2022 13:50:13 EDT //www.koonmotors.com/releases/2022/05/220516135013.htm //www.koonmotors.com/releases/2022/05/220511123615.htm Scientists describe a process for converting non-neuronal cells into functioning neurons able to take up residence in the brain, send out their fibrous branches across neural tissue, form synapses, dispense dopamine and restore capacities undermined by Parkinson's destruction of dopaminergic cells. Wed, 11 May 2022 12:36:15 EDT //www.koonmotors.com/releases/2022/05/220511123615.htm //www.koonmotors.com/releases/2022/05/220504144523.htm Neuroscientists found that higher levels of the alpha-synuclein protein in the brain can lead to changes in vocal production. Wed, 04 May 2022 14:45:23 EDT //www.koonmotors.com/releases/2022/05/220504144523.htm //www.koonmotors.com/releases/2022/04/220429144852.htm Scientists have carried out an extensive study of a newly discovered mutation that can uncover new insights into the molecular basis of pathology formation in a family of disorders that includes Lewy body dementia and Parkinson's disease. Fri, 29 Apr 2022 14:48:52 EDT //www.koonmotors.com/releases/2022/04/220429144852.htm //www.koonmotors.com/releases/2022/04/220407101048.htm Frontotemporal dementia patients with extrapyramidal symptoms have brainstem atrophy and reduced metabolism in certain areas of the brain significantly more often than patients without extrapyramidal symptoms, a new study shows. This observation can facilitate differential diagnostics in frontotemporal dementia. Thu, 07 Apr 2022 10:10:48 EDT //www.koonmotors.com/releases/2022/04/220407101048.htm //www.koonmotors.com/releases/2022/03/220323160653.htm Parkinsonism is a term for a group of neurological conditions that cause movement problems including tremors, slowed movement and stiffness, with Parkinson's disease being one of the better knowns causes. A new study suggests that older people taking statin drugs have a lower chance of developing parkinsonism later compared to people who were not taking statins. Wed, 23 Mar 2022 16:06:53 EDT //www.koonmotors.com/releases/2022/03/220323160653.htm //www.koonmotors.com/releases/2022/03/220322145738.htm A novel system to control protein aggregation in a model of Parkinson's disease may answer longstanding questions about how the disease begins and spreads, according to a new study. Initial results suggest that aggregation of the protein alpha-synuclein plays a critical role in disrupting neuronal homeostasis and triggering neurodegeneration. Tue, 22 Mar 2022 14:57:38 EDT //www.koonmotors.com/releases/2022/03/220322145738.htm //www.koonmotors.com/releases/2022/03/220317111909.htm Parkinson's disease is a neurodegenerative disorder characterized by the destruction of a specific population of neurons: the dopaminergic neurons. A team has investigated the destruction of these dopaminergic neurons using the fruit fly as study model. The scientists identified a key protein in flies, and also in mice, which plays a protective role against this disease and could be a new therapeutic target. Thu, 17 Mar 2022 11:19:09 EDT //www.koonmotors.com/releases/2022/03/220317111909.htm //www.koonmotors.com/releases/2022/03/220307113012.htm Hearing loss and epilepsy are early features of Parkinson's, according to pioneering new research. Mon, 07 Mar 2022 11:30:12 EST //www.koonmotors.com/releases/2022/03/220307113012.htm //www.koonmotors.com/releases/2022/02/220223094316.htm Study shows how blocking cellular housekeeping system leads to buildup and spread of abnormal protein aggregates in the brain. Wed, 23 Feb 2022 09:43:16 EST //www.koonmotors.com/releases/2022/02/220223094316.htm //www.koonmotors.com/releases/2022/02/220218100701.htm Specialized groups of neurons within the brainstem control movement. Now researchers have found that activation of such neurons is sufficient to restore full movement function in mice with symptoms of Parkinson's Disease. The study helps clinicians to focus Deep Brain Stimulation to the right therapeutic spot and hopefully could improve treatment of motor symptoms in Parkinson's Disease. Fri, 18 Feb 2022 10:07:01 EST //www.koonmotors.com/releases/2022/02/220218100701.htm //www.koonmotors.com/releases/2022/02/220216083011.htm People who have had a heart attack are at increased risk of stroke and vascular dementia; however, a new study found they may be less likely to develop Parkinson's disease. A large, nationwide study in Denmark found that the risk of Parkinson's disease was moderately lower among people who have had a heart attack than among the general population. Wed, 16 Feb 2022 08:30:11 EST //www.koonmotors.com/releases/2022/02/220216083011.htm //www.koonmotors.com/releases/2022/01/220126165540.htm People with Parkinson's Disease who eat more flavonoids -- compounds found in richly colored foods like berries, cocoa and red wine -- may have a lower mortality risk than those who don't, according to a new study. Wed, 26 Jan 2022 16:55:40 EST //www.koonmotors.com/releases/2022/01/220126165540.htm //www.koonmotors.com/releases/2022/01/220112181358.htm A new study suggests that people with early-stage Parkinson's disease who regularly got one to two hours of moderate exercise twice a week, like walking or gardening, may have less trouble balancing, walking and doing daily activities later. Wed, 12 Jan 2022 18:13:58 EST //www.koonmotors.com/releases/2022/01/220112181358.htm //www.koonmotors.com/releases/2022/01/220111153655.htm New findings provide a better understanding of how the synthesis of dopamine is regulated in the brain. It may shed new light on the mechanism behind diseases such as Parkinson's. Tue, 11 Jan 2022 15:36:55 EST //www.koonmotors.com/releases/2022/01/220111153655.htm //www.koonmotors.com/releases/2021/12/211223101419.htm Researchers have solved a decade-long mystery about a critical protein linked to Parkinson's disease that could help to fast-track treatments for the incurable disease. The research has produced a 'live action' view of the protein, called PINK1, in exquisite molecular detail. The discovery explains how the protein is activated in the cell, where it is responsible for initiating the removal and replacement of damaged mitochondria. When the protein is not working correctly, it can starve brain cells of energy, causing them to malfunction and -- in the long term -- die, as happens to dopamine-producing cells in Parkinson's disease. The discovery is the culmination of a project spanning eight years and provides the first detailed blueprint for the discovery and development of therapeutic agents that could help to slow or even stop the progression of Parkinson's disease. Thu, 23 Dec 2021 10:14:19 EST //www.koonmotors.com/releases/2021/12/211223101419.htm //www.koonmotors.com/releases/2021/12/211216145014.htm A common gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia, according to a new study. The results may help explain the accumulation of toxic iron in affected brain areas in the disease and provide a basis for the development of therapies designed to correct the iron trafficking defect. Thu, 16 Dec 2021 14:50:14 EST //www.koonmotors.com/releases/2021/12/211216145014.htm //www.koonmotors.com/releases/2021/12/211214135150.htm Researchers have shown that, at least in the test tube, the SARS-CoV-2 N-protein interacts with a neuronal protein called alpha-synuclein and speeds the formation of amyloid fibrils, pathological protein bundles that have been implicated in Parkinson's disease. Tue, 14 Dec 2021 13:51:50 EST //www.koonmotors.com/releases/2021/12/211214135150.htm //www.koonmotors.com/releases/2021/12/211209133929.htm A peptide known to prevent the protein error that gives rise to Parkinson's disease has been optimized by scientists. The new peptide is a strong candidate for future development into a cure. Thu, 09 Dec 2021 13:39:29 EST //www.koonmotors.com/releases/2021/12/211209133929.htm //www.koonmotors.com/releases/2021/12/211201150115.htm A new study has identified a promising drug candidate to minimize uncontrolled, erratic muscle movements, called dyskinesia, associated with Parkinson's disease. Wed, 01 Dec 2021 15:01:15 EST //www.koonmotors.com/releases/2021/12/211201150115.htm //www.koonmotors.com/releases/2021/11/211113072244.htm In an unexpected discovery, researchers have identified what appears to be a significant vascular defect in patients with moderately severe Parkinson's disease. The finding could help explain an earlier outcome of the same study, in which the drug nilotinib was able to halt motor and non-motor (cognition and quality of life) decline in the long term. Sat, 13 Nov 2021 07:22:44 EST //www.koonmotors.com/releases/2021/11/211113072244.htm