Huntington's Disease News -- ScienceDaily
//www.koonmotors.com/news/mind_brain/huntington's_disease/
阅读最新研究亨廷顿氏Dise新闻ase. Learn about genetic risks, potential new treatments and more.
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Wed, 06 Sep 2023 14:48:40 EDT
Wed, 06 Sep 2023 14:48:40 EDT
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Huntington's Disease News -- ScienceDaily
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For more science news, visit ScienceDaily.
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Study uncovers potential new source of genetic mutations that cause neurodegenerative disease
//www.koonmotors.com/releases/2023/08/230817163900.htm
An international team of scientists has discovered an additional potential cause of the genetic mutations that result in rare neurodegenerative conditions such as Huntington's disease.
Thu, 17 Aug 2023 16:39:00 EDT
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Drug significantly reduces chorea symptoms in patients with Huntington's disease
//www.koonmotors.com/releases/2023/05/230519104538.htm
The drug valbenazine statistically improves chorea, a movement disorder commonly associated with Huntington's disease, when compared to a placebo.
Fri, 19 May 2023 10:45:38 EDT
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Cold is beneficial for healthy aging, at least in animals
//www.koonmotors.com/releases/2023/04/230403133449.htm
A lower body temperature is one of the most effective mechanisms to prolong the lifespan of animals. New research has now described precisely how this works. The scientists show that cold can prevent the pathological aggregation of proteins typical for two aging-associated neurodegenerative diseases.
Mon, 03 Apr 2023 13:34:49 EDT
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How Huntington's disease affects different neurons
//www.koonmotors.com/releases/2023/01/230120130916.htm
Neuroscientists find two distinct cell populations in the striatum are affected differently by Huntington's disease. They believe neurodegeneration of one of these populations leads to motor impairments, while damage to the other population, located in a structure called the striosome, may account for the mood disorders that are often see in the early stages of the disease.
Fri, 20 Jan 2023 13:09:16 EST
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Cellular housekeeping process implicated in fatal neurological disorder
//www.koonmotors.com/releases/2022/10/221028121017.htm
A study shows that as patients age, Huntington's disease impairs autophagy, which eliminates waste from cells. This housekeeping is significant in Huntington's because a buildup of waste in a specific kind of neuron leads to such cells' untimely deaths. The researchers also showed that enhancing the autophagy pathway in such neurons that were created from skin cells of Huntington's patients protects those cells from dying.
Fri, 28 Oct 2022 12:10:17 EDT
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Establishing a novel strategy to tackle Huntington's disease
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A new platform takes on Huntington's disease via an innovative approach.
Fri, 02 Sep 2022 09:06:43 EDT
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Brain's support cells may hold key to new Huntington's treatments
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A growing body of research suggests that the disease may also flow from defects in glia, important support cells found in the brain. The new study expands our understanding of the underlying mechanisms of the disease, and reinforces the potential of therapies that target glia cells.
Tue, 30 Aug 2022 13:16:02 EDT
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Researchers reprogram human skin cells to aged neurons to study neurodegenerative disorders
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Researchers have developed a new method for studying age-related brain disorders. The researchers have focused on the neurodegenerative disorder Huntington's disease.
Wed, 17 Aug 2022 10:39:59 EDT
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Huntington's, ALS: Where the body fails
//www.koonmotors.com/releases/2022/02/220216153908.htm
Huntington's, Alzheimer's, ALS, and multiple other neurodegenerative diseases share a commonality: they are all characterized by proteins (different ones for each disease) aggregating in neurons within the brain and nervous system. Now, scientists have found that the cells have the mechanisms to clear those aggregates -- they just fail to activate them.
Wed, 16 Feb 2022 15:39:08 EST
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A new atlas of cells that carry blood to the brain
//www.koonmotors.com/releases/2022/02/220215125507.htm
Researchers created a comprehensive atlas of the types of cells found in the brain cerebrovasculature, which provides oxygen and nutrients to the brain and helps form the blood-brain barrier. They also found significant differences between healthy cells and those from Huntington's disease patients.
Tue, 15 Feb 2022 12:55:07 EST
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New mouse model to shed light on the mystery surrounding Huntington’s disease onset and improve the targeting of potential therapies
//www.koonmotors.com/releases/2022/02/220202111740.htm
研究人员已经开发出一种新的小鼠模型ntington's disease that recapitulates more Huntington's disease-like characteristics than earlier models, providing new clues to the disease and giving researchers a powerful new tool to test new therapies.
2022年2月结婚,02年11:17:40 EST
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Study detects origins of Huntington's disease in two-week-old human embryos
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The findings shed new light on the root causes of this disease, which leads to the degeneration of neurons in midlife.
Tue, 05 Oct 2021 12:47:19 EDT
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New study puts focus on early symptoms of Huntington’s disease
//www.koonmotors.com/releases/2021/09/210907160628.htm
在一个ea精神和认知症状出现rly stage in Huntington's disease. However, research so far has mainly focused on movement impairment, a symptom associated with the more advanced stages of the disease. A new study now shows that the emotional brain - the limbic system - is affected earlier in the course of the disease, and should therefore be given more attention in the development of new treatments.
Tue, 07 Sep 2021 16:06:28 EDT
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Flawed quality control in the brain
//www.koonmotors.com/releases/2021/08/210819102709.htm
Proteins are the 'tools' of our cells – they are essential to all vital tasks. However, they are only able to do their jobs if they fold correctly and adopt their respective, very specific 3D structure. To ensure that nothing goes wrong with the folding process, it is strictly monitored in the cell. The consequences of a flawed quality control can be seen, for example, in the deposition of misfolded proteins in neurodegenerative diseases such as Alzheimer's. Researchers have now developed a mouse line that makes the state of protein balance visible in the mammalian brain for the first time. In this way, the processes of protein quality control can now be studied in healthy and diseased neurons in more detail.
Thu, 19 Aug 2021 10:27:09 EDT
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Gene therapy in early stages of Huntington's disease may slow down symptom progression
//www.koonmotors.com/releases/2021/07/210707112510.htm
In a new study on mice, researchers report that using MRI scans to measure blood volume in the brain can serve as a noninvasive way to potentially track the progress of gene editing therapies for early-stage Huntington's disease, a neurodegenerative disorder that attacks brain cells.
Wed, 07 Jul 2021 11:25:10 EDT
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Success in reversing dementia in mice sets the stage for human clinical trials
//www.koonmotors.com/releases/2021/06/210629120756.htm
Researchers have identified a new treatment candidate that appears to not only halt neurodegenerative symptoms in mouse models of dementia and Alzheimer's disease, but also reverse the effects of the disorders.
Tue, 29 Jun 2021 12:07:56 EDT
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Glial cells help mitigate neurological damage in Huntington's disease
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Glia affected by Huntington's disease respond by tuning down synapse genes, which has a protective effect.
Thu, 24 Jun 2021 13:55:57 EDT
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Huntington's disease driven by slowed protein-building machinery in cells
//www.koonmotors.com/releases/2021/03/210305123800.htm
The gene for Huntington's disease was found nearly 40 years ago, yet there are no approved treatments. A new study shows the problem may lie with slowed protein assembly.
Fri, 05 Mar 2021 12:38:00 EST
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Basic cell health systems wear down in Huntington's disease, novel analysis shows
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A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis. The 'Geomic' approach can be applied to other diseases, authors say.
Tue, 23 Feb 2021 11:04:28 EST
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Researchers link cases of ALS and FTD to a Huntington's disease-associated mutation
//www.koonmotors.com/releases/2020/12/201204110241.htm
A study has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington's disease. This large, international project opens a potentially new avenue for diagnosing and treating some individuals with FTD or ALS.
Fri, 04 Dec 2020 11:02:41 EST
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Novel pathology could improve diagnosis and treatment of Huntington's and other diseases
//www.koonmotors.com/releases/2020/06/200630103612.htm
Scientists have discovered a novel pathology that occurs in several human neurodegenerative diseases, including Huntington's disease. The article describes how SAFB1 expression occurs in both spinocerebellar ataxias and Huntington's disease and may be a common marker of these conditions, which have a similar genetic background.
Tue, 30 Jun 2020 10:36:12 EDT
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High doses of ketamine can temporarily switch off the brain
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Researchers have identified two brain phenomena that may explain some of the side-effects of ketamine. Their measurements of the brain waves of sheep sedated by the drug may explain the out-of-body experience and state of complete oblivion it can cause.
Thu, 11 Jun 2020 09:41:27 EDT
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Antihistamines and similar drugs could slow down Huntington's disease
//www.koonmotors.com/releases/2020/06/200609122920.htm
科学家们描述了一个潜在的新therapeutic strategy for slowing down early-stage Huntington's disease.
Tue, 09 Jun 2020 12:29:20 EDT
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New method to map cholesterol metabolism in brain
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Researchers have developed new technology to monitor cholesterol in brain tissue which could uncover its relation to neurodegenerative disease and pave the way for the development of new treatments.
Fri, 29 May 2020 15:06:12 EDT
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Optimal time to treat Huntington's disease identified
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The earliest brain changes due to Huntington's disease can be detected 24 years before clinical symptoms show, according to a new study.
Tue, 26 May 2020 20:36:02 EDT
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Immune molecule's complex role in Huntington's disease
//www.koonmotors.com/releases/2020/05/200526145319.htm
Knocking out the immune cytokine IL-6 exacerbates symptoms in HD model mice and affects neural connection genes, a new study finds.
Tue, 26 May 2020 14:53:19 EDT
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When damaged, the adult brain repairs itself by going back to the beginning
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When adult brain cells are injured, they revert to an embryonic state, say researchers. In their newly adopted immature state, the cells become capable of re-growing new connections that, under the right conditions, can help to restore lost function.
结婚,2020年4月15日13:36:54 EDT
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Huntington's disease-causing DNA repeat mutations reversed in the lab
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An international team of researchers identifies a compound that corrects genetic abnormalities involved in the onset and progression of Huntington's disease for which there is no definitive treatment. They successfully reversed disease-causing DNA expansion mutations with no off-target effects in the lab. They hope that their discovery may help treat other DNA repeat diseases like myotonic dystrophy.
Thu, 27 Feb 2020 11:45:28 EST
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Genetic screen offers new drug targets for Huntington's disease
//www.koonmotors.com/releases/2020/01/200130144530.htm
Using a genetic screen that was previously impossible in the mammalian brain, neuroscientists have identified hundreds of genes that are necessary for neuron survival. They also used the approach to identify genes that contribute to the toxic effects of mutant protein that causes Huntington's disease.
Thu, 30 Jan 2020 14:45:30 EST
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Q-suite motor assessment tool promising for evaluating Huntington's disease
//www.koonmotors.com/releases/2019/10/191022115223.htm
In clinical trials of adults with Huntington's disease (HD) the Q-Suite Motor Assessment Tool (Q-Motor) has proven to be helpful to detect and quantitate subtle motor abnormalities. With the anticipated arrival of preventive gene therapies that will most likely be administered to young children known to be carriers of the HD mutation, it is crucial to have a means to evaluate motor abilities in children that is sensitive to the child's stage of development.
Tue, 22 Oct 2019 11:52:23 EDT
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Clues to the origin of Huntington's disease, and a new way to find drugs
//www.koonmotors.com/releases/2019/09/190917115451.htm
Using a new technique to study brain development, scientists were able to trace the causes of Huntington's back to early developmental stages when the brain has only just begun to form.
Tue, 17 Sep 2019 11:54:51 EDT
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Insight into cells' 'self-eating' process could pave the way for new dementia treatments
//www.koonmotors.com/releases/2019/08/190821082220.htm
Cells regularly go through a process called autophagy -- literally translated as 'self-eating' -- which helps to destroy bacteria and viruses after infection. Now new research has shed light on the mechanisms behind autophagy and how it progresses -- particularly relating to a process called liquid-liquid phase separation (LLPS).
Wed, 21 Aug 2019 08:22:20 EDT
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The surprising link between a babies' weeble-wobble and the genetics of motor control
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Neuroscientists have revealed that complex movements, such as those that maintain our posture, can be controlled by a simple genetic system, providing a framework to better understand the molecular basis of diseases that affect motor control, like Huntington's and Parkinson's.
Tue, 30 Jul 2019 10:10:19 EDT
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Searching for the origins of the depressive symptoms in Huntington's disease
//www.koonmotors.com/releases/2019/05/190531100556.htm
An altered function of Cdk5 kinase -- an essential enzyme in several cell signalling pathways -- could explain the physiopathology of the depressive-like behavior in Huntington's disease.
Fri, 31 May 2019 10:05:56 EDT
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Why adults at risk for Huntington's choose not to learn if they inherited deadly gene
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As many as 90 percent of individuals who have a parent with Huntington's disease (HD) choose not to take a gene test that reveals if they will also develop the fatal disorder -- and a new study details the reasons why. Understanding the ''why'' matters as new clinical trials testing therapies for people who haven't yet developed symptoms of Huntington disease requires participants to be tested for the HD gene to be included in the trials.
Thu, 16 May 2019 10:37:15 EDT
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How mutations lead to neurodegenerative disease
//www.koonmotors.com/releases/2019/05/190513100550.htm
Scientists have discovered how mutations in DNA can cause neurodegenerative disease. The discovery is an important step towards better treatment to slow the progression or delay onset in a range of incurable diseases such as Huntington's and motor neurone disease - possibly through the use, in new ways, of existing anti-inflammatory drugs.
Mon, 13 May 2019 10:05:50 EDT
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Blood pressure drug shows promise for treating Parkinson's and dementia in animal study
//www.koonmotors.com/releases/2019/04/190418080750.htm
A prescribed drug to treat high blood pressure has shown promise against conditions such as Parkinson's, Huntington's and forms of dementia in studies carried out in mice and zebrafish.
Thu, 18 Apr 2019 08:07:50 EDT
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New role for sensory signals in the brain
//www.koonmotors.com/releases/2019/04/190411145134.htm
Learning how to tie a shoe or shoot a basketball isn't easy, but the brain somehow integrates sensory signals that are critical to coordinating movements so you can get it right. Now, scientists have discovered that sensory signals in the brain's cerebral cortex, which plays a key role in controlling movement and other functions, have a different pattern of connections between nerve cells and different effects on behavior than motor signals. The motor area of the cortex sends signals to stimulate muscles.
Thu, 11 Apr 2019 14:51:34 EDT
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Abnormalities in a protein affecting how nerve cells change shape
//www.koonmotors.com/releases/2019/04/190403113914.htm
Since 1993, when the gene that causes Huntington's disease (HD) was identified, there has been intense focus on understanding how this genetic mutation causes the disease's severe progressive neural deterioration.
Wed, 03 Apr 2019 11:39:14 EDT
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Circadian clock plays unexpected role in neurodegenerative diseases
//www.koonmotors.com/releases/2019/04/190402113220.htm
Researchers induced jet lag in a fruit fly model of Huntington disease and found that jet lag protected the flies' neurons.
Tue, 02 Apr 2019 11:32:20 EDT
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How nerve cells control misfolded proteins
//www.koonmotors.com/releases/2019/03/190327112652.htm
研究人员发现了一种蛋白复合物marks misfolded proteins, stops them from interacting with other proteins in the cell and directs them towards disposal. They have identified the so-called Linear Ubiquitin Chain Assembly Complex, Lubac for short, as a crucial player in controlling misfolded proteins in cells. The group is hoping to find a new therapeutic approach to treat neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's chorea, all of which are associated with misfolded proteins.
Wed, 27 Mar 2019 11:26:52 EDT
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West Virginia study details promising method for estimating rural intravenous drug use
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A study estimates that 1,857 people injected drugs in the last six months in Cabell County, W.Va., a rural county with a population of 94,958. This estimate is based on an innovative survey technique that public health officials can now use in their own rural communities to address the opioid epidemic.
Thu, 24 Jan 2019 17:14:19 EST
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Speeding up genetic diagnosis of Huntington's disease
//www.koonmotors.com/releases/2019/01/190110101415.htm
Elongated segments of DNA cause Huntington's disease and certain other disorders of the brain. Researchers have developed a method to determine the length of the mutated genes quickly and easily.
Thu, 10 Jan 2019 10:14:15 EST
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A new hope in treating neurodegenerative disease
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Researchers have clarified the fundamentals of coiled toxin protein which causes neurodegenerative brain disorders. The result is expected to speed the development of treatment for neurodegenerative disorder.
Fri, 04 Jan 2019 10:40:12 EST
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How neurons could disconnect from each other in Huntington's disease
//www.koonmotors.com/releases/2018/12/181225162629.htm
Newly described mechanism called 'neuritosis' could play an important role in normal brain development, aging and neurodegenerative disease.
Tue, 25 Dec 2018 16:26:29 EST
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The brain's support cells show defective development in Huntington's disease
//www.koonmotors.com/releases/2018/12/181221123813.htm
The neurological disorder Huntington's disease causes behavioral and motor changes, which among other things are a result of dysfunctional maturation or formation of glial cells, the brain's support cells, researchers demonstrate in a new study based on mice trials. The researchers' long-term goal is to be able to use the research results to develop a treatment for Huntington's disease using glial cells.
Fri, 21 Dec 2018 12:38:13 EST
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New study offers hope for patients suffering from a rare form of blindness
//www.koonmotors.com/releases/2018/11/181101142900.htm
A new form of therapy may halt or even reverse a form of progressive vision loss that, until now, has inevitably led to blindness. This hyper-targeted approach offers hope to individuals living with spinocerebellar ataxia type 7 (SCA7) and validates a new form of therapy with the potential to treat neurogenetic diseases effectively and with far fewer side effects than other medications.
Thu, 01 Nov 2018 14:29:00 EDT
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Blood and brain fluid change first in Huntington's disease
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A simple blood test can detect the earliest changes caused by Huntington's disease, even before scans can pick up any signs in the brain, a new study has found.
Wed, 12 Sep 2018 14:44:23 EDT
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Predict the onset and course of Huntington's disease
//www.koonmotors.com/releases/2018/09/180906141549.htm
Short protein fibers precede the formation of larger deposits that accumulate in the brains of those affected by the incurable Huntington's disease, sometimes called Huntington's chorea, researchers report. These results could improve diagnosis and help in the search for new medications.
Thu, 06 Sep 2018 14:15:49 EDT
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Earlier diagnosis, potential therapy for Huntington's disease suggested in new research
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A new study suggests that Huntington's disease may take effect much earlier in life than was previously believed, and that a new drug may be key in controlling the disease.
Tue, 04 Sep 2018 14:05:52 EDT
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Powerful molecules provide new findings about Huntington's disease
//www.koonmotors.com/releases/2018/08/180821112021.htm
Researchers have discovered a direct link between the protein aggregation in nerve cells that is typical for neurodegenerative diseases, and the regulation of gene expression in Huntington's disease. The results pave the way for the development of new treatment strategies for diseases that involve impairment of the basic mechanism by which the body's cells can break down and recycle their own component parts. This process, called autophagy, is disrupted in for example Huntington's and other neurodegenerative diseases.
Tue, 21 Aug 2018 11:20:21 EDT
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Researchers discover system that could reduce neurodegeneration in Huntington's disease
//www.koonmotors.com/releases/2018/07/180726161058.htm
Neuroscientists have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease. Particularly, they identified a system blocking the accumulation of toxin protein aggregates, which are responsible for neurodegeneration.
Thu, 26 Jul 2018 16:10:58 EDT
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Powerful new approach helps understand molecular alterations in neurological disease
//www.koonmotors.com/releases/2018/06/180620150235.htm
Scientists have developed a high-throughput, multi-pronged approach that integrates laboratory experiments, data from published literature and network analysis of large datasets to identify genes that drive disease.
Wed, 20 Jun 2018 15:02:35 EDT
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New piece in the Huntington's disease puzzle
//www.koonmotors.com/releases/2018/06/180620100605.htm
Researchers have discovered a previously unknown error in the transport of glutamine between astrocytes and neurons in the brain of mice with Huntington's disease. At the same time, it is a relevant area on which to focus the effort of developing a future treatment for the disease, the researchers believe.
Wed, 20 Jun 2018 10:06:05 EDT
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Pig model of Huntington's offers advantages for testing treatments
//www.koonmotors.com/releases/2018/03/180329141047.htm
A team of scientists has established a 'knock in' pig model of Huntington's disease (HD), an inherited neurodegenerative disease, anticipated to be useful for testing treatments.
Thu, 29 Mar 2018 14:10:47 EDT
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Medical tests with less fear
//www.koonmotors.com/releases/2018/03/180321111143.htm
It is a principle of modern architecture that less may be more. This principle does not apply to information as a basis of far-reaching decisions, it seems. But: Many people shy away from going to the doctor’s, because they are afraid of unpleasant truths, such as the diagnosis of a disease. Researchers have developed a method to overcome this fear.
Wed, 21 Mar 2018 11:11:43 EDT
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Strict eating schedule can lower Huntington disease protein in mice
//www.koonmotors.com/releases/2018/03/180306085409.htm
New research suggests that following a strict eating schedule can help clear away the protein responsible for Huntington disease in mice.
Tue, 06 Mar 2018 08:54:09 EST
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Decoding the structure of huntingtin
//www.koonmotors.com/releases/2018/02/180222125725.htm
Determining the three dimensional structure of the huntingtin protein could help develop new treatments for Huntington's disease.
Thu, 22 Feb 2018 12:57:25 EST
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Huntington's disease provides new cancer weapon
//www.koonmotors.com/releases/2018/02/180212084458.htm
Patients with Huntington's disease, a fatal genetic illness that causes the breakdown of nerve cells in the brain, have up to 80 percent less cancer than the general population. Scientists have discovered why Huntington's is so toxic to cancer cells and harnessed it for a novel approach to treat cancer, a new study reports.
Mon, 12 Feb 2018 08:44:58 EST
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Altering Huntington's patients' skin cells into brain cells sheds light on disease
//www.koonmotors.com/releases/2018/02/180205143357.htm
Scientists have transformed skin cells from patients with Huntington's disease into the type of brain cell affected by the disorder. The resulting mass of neurons serves as a new tool to study the degenerative and eventually fatal neurological condition, according to the researchers.
Mon, 05 Feb 2018 14:33:57 EST
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