计画ps://www.koonmotors.com/news/health_medicine/pharmacology/ Drug discovery. Read the latest in new drug development and pharmacology from leading research institutes around the world. en-us Sat, 01 Jul 2023 09:17:43 EDT Sat, 01 Jul 2023 09:17:43 EDT 60 计画ps://www.koonmotors.com/images/scidaily-logo-rss.png计画ps://www.koonmotors.com/news/health_medicine/pharmacology/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/06/230630123231.htm An analysis on the positive effects of exercise on blood sugar levels in people with Type 2 diabetes shows that while all exercise helps, certain activities -- and their timing -- are extremely good for people's health. Fri, 30 Jun 2023 12:32:31 EDT //www.koonmotors.com/releases/2023/06/230630123231.htm //www.koonmotors.com/releases/2023/06/230630123122.htm A new study has revealed the most extensive analysis to date on what led to the eventual heart failure in the world's first successful transplant of a genetically-modified pig heart into a human patient. Fri, 30 Jun 2023 12:31:22 EDT //www.koonmotors.com/releases/2023/06/230630123122.htm //www.koonmotors.com/releases/2023/06/230629125734.htm Researchers have assisted microbiologists in Ukraine in investigating bacterial resistance among the war-wounded patients treated in hospitals. The results reveal that many of the patients were affected by bacteria that exhibited an extremely high level of antibiotic resistance. Thu, 29 Jun 2023 12:57:34 EDT //www.koonmotors.com/releases/2023/06/230629125734.htm //www.koonmotors.com/releases/2023/06/230628201318.htm Researchers have developed a new method to deliver drugs into the inner ear. The discovery was possible by harnessing the natural flow of fluids in the brain and employing a little understood backdoor into the cochlea. When combined to deliver a gene therapy that repairs inner ear hair cells, the researchers were able to restore hearing in deaf mice. Wed, 28 Jun 2023 20:13:18 EDT //www.koonmotors.com/releases/2023/06/230628201318.htm //www.koonmotors.com/releases/2023/06/230628130420.htm Scientists say they have developed a nanoparticle -- an extremely tiny biodegradable container -- that has the potential to improve the delivery of messenger ribonucleic acid (mRNA)-based vaccines for infectious diseases such as COVID-19, and vaccines for treating non-infectious diseases including cancer. Wed, 28 Jun 2023 13:04:20 EDT //www.koonmotors.com/releases/2023/06/230628130420.htm //www.koonmotors.com/releases/2023/06/230628130408.htm In an exciting new study adding to the global pool of knowledge about the roots of human cancers, researchers are establishing a clear link between different types of cancers and their embryonic origins. They also identify new concepts that can be considered in future drug discovery projects and used in standard chemotherapeutics in the clinic. Wed, 28 Jun 2023 13:04:08 EDT //www.koonmotors.com/releases/2023/06/230628130408.htm //www.koonmotors.com/releases/2023/06/230628125341.htm Researchers find a combination of drugs outperformed other treatments in human and mouse models of pancreatic cancer; now urge clinical trial. Wed, 28 Jun 2023 12:53:41 EDT //www.koonmotors.com/releases/2023/06/230628125341.htm //www.koonmotors.com/releases/2023/06/230628125327.htm Scientists have developed a new approach to produce life-saving oligonucleotide therapeutics on a large scale, in high purity, and with minimal environmental impacts. Wed, 28 Jun 2023 12:53:27 EDT //www.koonmotors.com/releases/2023/06/230628125327.htm //www.koonmotors.com/releases/2023/06/230627225228.htm A new study found that once-daily oral semaglutide taken at 25 milligrams (mg) and 50 mg did a better job in lowering blood sugar levels and promoting weight loss than the lowest dose of 14 mg. The new study is in line with other studies, which are pushing for the use of oral GLP-1 receptor agonists as a treatment for obesity. Tue, 27 Jun 2023 22:52:28 EDT //www.koonmotors.com/releases/2023/06/230627225228.htm //www.koonmotors.com/releases/2023/06/230627225220.htm Researchers have solved a long-standing mystery about how a protein helps rid the body of damaged mitochondria, in findings that could help lead to potential new treatments for Parkinson's disease. Tue, 27 Jun 2023 22:52:20 EDT //www.koonmotors.com/releases/2023/06/230627225220.htm //www.koonmotors.com/releases/2023/06/230627191524.htm As we age, our bodies change and degenerate over time in a process called senescence. Stem cells, which have the unique ability to change into other cell types, also experience senescence, which presents an issue when trying to maintain cell cultures for therapeutic use. The biomolecules produced by these cell cultures are important for various medicines and treatments, but once the cells enter a senescent state they stop producing them, and worse, they instead produce biomolecules antagonistic to these therapeutics. In a recently published study, researchers describe a new method for reversing senescence in stem cells through delivering antioxidants in the form of a crystal. Tue, 27 Jun 2023 19:15:24 EDT //www.koonmotors.com/releases/2023/06/230627191524.htm //www.koonmotors.com/releases/2023/06/230626164131.htm Novel research found that apparent resistant hypertension (aRH) prevalence was lower in a real-world sample than previously reported, but still relatively frequent -- affecting nearly 1 in 10 hypertensive patients. Mon, 26 Jun 2023 16:41:31 EDT //www.koonmotors.com/releases/2023/06/230626164131.htm //www.koonmotors.com/releases/2023/06/230623161153.htm Using 3-D models of ovarian cancer tumors, scientists found differences in gene activity based on where a cell is in a tumor, demonstrating how a cell's location and environment in a cancerous tumor can strongly influence which genes are active and the cell's role in the cancer's biology. Fri, 23 Jun 2023 16:11:53 EDT //www.koonmotors.com/releases/2023/06/230623161153.htm //www.koonmotors.com/releases/2023/06/230623161134.htm Researchers report that, in laboratory cultures and animal models, a drug significantly reduces the ability of bacteria to develop antibiotic resistance, which might prolong antibiotic effectiveness. Fri, 23 Jun 2023 16:11:34 EDT //www.koonmotors.com/releases/2023/06/230623161134.htm //www.koonmotors.com/releases/2023/06/230623161123.htm The discovery of new genes linked to IgA nephropathy, a common kidney disease, confirms the idea that the immune system drives the disease. Fri, 23 Jun 2023 16:11:23 EDT //www.koonmotors.com/releases/2023/06/230623161123.htm //www.koonmotors.com/releases/2023/06/230622182828.htm Researchers invented a new reporting technique to monitor activity of CaMKII while screening the effects of nearly 5,000 FDA approved drugs on human cells that expressed the enzyme. The screen identified five previously unknown CaMKII inhibitors; ruxolitinib, which is used to treat cancers of the blood and bone marrow, along with skin conditions like atopic dermatitis and vitiligo, was the most effective. Thu, 22 Jun 2023 18:28:28 EDT //www.koonmotors.com/releases/2023/06/230622182828.htm //www.koonmotors.com/releases/2023/06/230622182820.htm Just as space holds infinite mysteries, when we zoom in at the level of biomolecules (one trillion times smaller than a meter), there is still so much to learn. Scientists are studying the conformational landscapes of biomolecules and how they modulate cell function. When biomolecules receive certain inputs, it can cause the atoms to rearrange and the biomolecule to change shape. This change in shape affects their function in cells, so understanding conformational dynamics is critical for drug development. Thu, 22 Jun 2023 18:28:20 EDT //www.koonmotors.com/releases/2023/06/230622182820.htm //www.koonmotors.com/releases/2023/06/230622142348.htm graft-versus-ho临床医生有一个新的标准st disease (GVHD) prevention after allogeneic hematopoietic stem cell transplantation, according to results from a phase III study. The new standard is more effective at preventing GVHD and came with less side effects, compared with the current gold standard. Thu, 22 Jun 2023 14:23:48 EDT //www.koonmotors.com/releases/2023/06/230622142348.htm //www.koonmotors.com/releases/2023/06/230622120820.htm The herpes simplex virus-1 can sometimes cause a dangerous brain infection. Combining an anti-inflammatory and an antiviral could help in these cases, report scientists. Thu, 22 Jun 2023 12:08:20 EDT //www.koonmotors.com/releases/2023/06/230622120820.htm //www.koonmotors.com/releases/2023/06/230621164651.htm Researchers have discovered that extracts from plants used by the Kwakwaka'wakw First Nations peoples in their traditional botanical medicine practices are able to rescue the function of ion channel proteins carrying mutations that cause human Episodic Ataxia. Wed, 21 Jun 2023 16:46:51 EDT //www.koonmotors.com/releases/2023/06/230621164651.htm //www.koonmotors.com/releases/2023/06/230621121024.htm Researchers have outlined the structure and function of a protein complex which is required to repair damaged DNA and protect against cancer. Wed, 21 Jun 2023 12:10:24 EDT //www.koonmotors.com/releases/2023/06/230621121024.htm //www.koonmotors.com/releases/2023/06/230621105440.htm A study has shown that prazosin, a drug used to treat high blood pressure, can prevent post-traumatic headaches. Wed, 21 Jun 2023 10:54:40 EDT //www.koonmotors.com/releases/2023/06/230621105440.htm //www.koonmotors.com/releases/2023/06/230621105419.htm Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers have developed a microgel delivery system for probiotics that keeps 'good' bacteria safe while actively clearing out 'bad' ones. In mice, the system treated intestinal inflammation without side effects. Wed, 21 Jun 2023 10:54:19 EDT //www.koonmotors.com/releases/2023/06/230621105419.htm //www.koonmotors.com/releases/2023/06/230614220653.htm Researchers develop new diagnostic tool to visualize protein biomarkers of well-developed sperm to determine if surgical sperm extraction may be successful for certain infertile men. Wed, 14 Jun 2023 22:06:53 EDT //www.koonmotors.com/releases/2023/06/230614220653.htm //www.koonmotors.com/releases/2023/06/230614220548.htm A new, biodegradable ultrasound far more powerful than previous devices could make brain cancers more treatable, researchers report. Wed, 14 Jun 2023 22:05:48 EDT //www.koonmotors.com/releases/2023/06/230614220548.htm //www.koonmotors.com/releases/2023/06/230613190832.htm Inhaled microplastics can pose serious health risks, so understanding how they travel in the respiratory system is essential for prevention and treatment of respiratory diseases. Researchers develop a computational fluid dynamics model to analyze microplastic transport and deposition in the upper airway. The team explored the movement of microplastics with different shapes and sizes and under slow and fast breathing conditions. Microplastics tended to collect in hot spots in the nasal cavity and oropharynx, or back of the throat. Tue, 13 Jun 2023 19:08:32 EDT //www.koonmotors.com/releases/2023/06/230613190832.htm //www.koonmotors.com/releases/2023/06/230613105518.htm Cognitive deficits accompany mood disorders and other psychiatric conditions, often with debilitating effects. Limited treatments currently exist, but studies in animals and humans have pointed to drugs such as the laxative prucalopride that activate serotonin receptors as a potential therapeutic for the symptoms. It has remained unclear, however, how the medication affects resting brain activity. Now, a new study examines the drug's effects in healthy human adults. Tue, 13 Jun 2023 10:55:18 EDT //www.koonmotors.com/releases/2023/06/230613105518.htm //www.koonmotors.com/releases/2023/06/230612200436.htm A decade after scientists identified an over-the-counter antihistamine as a treatment for multiple sclerosis, researchers have developed an approach to measure the drug's effectiveness in repairing the brain, making it possible to also assess future therapies for the devastating disorder. Mon, 12 Jun 2023 20:04:36 EDT //www.koonmotors.com/releases/2023/06/230612200436.htm //www.koonmotors.com/releases/2023/06/230612200349.htm Asthma is more dangerous than many people realize. An estimated 10 Americans die every day from asthma, and the disease leads to around 439,000 hospitalizations and 1.3 million emergency room trips each year. Mon, 12 Jun 2023 20:03:49 EDT //www.koonmotors.com/releases/2023/06/230612200349.htm //www.koonmotors.com/releases/2023/06/230612200332.htm Researchers are describing the results of a recent clinical trial -- a breakthrough in glioblastoma treatment with the help of a modified cold virus injected directly into the tumor. When combined with an immunotherapy drug, the authors observed a subset of patients that appeared to be living longer as a result of this therapy. Mon, 12 Jun 2023 20:03:32 EDT //www.koonmotors.com/releases/2023/06/230612200332.htm //www.koonmotors.com/releases/2023/06/230609125736.htm A model known as ConPLex can predict whether potential drug molecules will interact with specific protein targets, without having to perform the computationally intensive calculation of the molecules' structures. By applying a language model to protein-drug interactions, researchers can quickly screen large libraries of potential drug compounds. Fri, 09 Jun 2023 12:57:36 EDT //www.koonmotors.com/releases/2023/06/230609125736.htm //www.koonmotors.com/releases/2023/06/230608121022.htm 有没有想过药物达到圆盾ts and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane. One such receptor involved in relaying molecular signals is a G protein-coupled receptor (GPCR). About one-third of existing drugs work by controlling the activation of this protein. Researchers now reveal a new way of activating GPCR by triggering shape changes in the intracellular region of the receptor. This new process can help researchers design drugs with fewer or no side effects. Thu, 08 Jun 2023 12:10:22 EDT //www.koonmotors.com/releases/2023/06/230608121022.htm //www.koonmotors.com/releases/2023/06/230607215842.htm New research finds an unexpected link between chromosomal instability and epigenetic alternations, both of which are hallmarks of cancer -- especially advanced, drug-resistant cancers. Wed, 07 Jun 2023 21:58:42 EDT //www.koonmotors.com/releases/2023/06/230607215842.htm //www.koonmotors.com/releases/2023/06/230606164816.htm Could the next weapon against malaria come from a better understanding of biological clocks? A new study shows that malaria parasites sync their gene activity with the circadian rhythms of their host, like two pendulum clocks with synchronized swings. If scientists can identify the molecular signals behind this mysterious synchronicity, they might be able to develop new anti-malarial drugs that throw malaria's internal clock out of step with its host, essentially 'jet-lagging' the parasites. Tue, 06 Jun 2023 16:48:16 EDT //www.koonmotors.com/releases/2023/06/230606164816.htm //www.koonmotors.com/releases/2023/06/230606111700.htm A research collaboration between Cornell and the Max Planck Institute for Intelligent Systems has found an efficient way to expand the collective behavior of swarming microrobots: Mixing different sizes of the micron-scale 'bots enables them to self-organize into diverse patterns that can be manipulated when a magnetic field is applied. The technique even allows the swarm to 'cage' passive objects and then expel them. Tue, 06 Jun 2023 11:17:00 EDT //www.koonmotors.com/releases/2023/06/230606111700.htm //www.koonmotors.com/releases/2023/06/230605181325.htm 基因,使细菌对抗生素耐药are much more widespread in our environment than was previously realized. A new study shows that bacteria in almost all environments carry resistance genes, with a risk of them spreading and aggravating the problem of bacterial infections that are untreatable with antibiotics. Mon, 05 Jun 2023 18:13:25 EDT //www.koonmotors.com/releases/2023/06/230605181325.htm //www.koonmotors.com/releases/2023/06/230605181244.htm Governments around the world must do more to tackle the growing threat of drug-resistant infections, according to new research. Antimicrobial resistance (AMR) occurs when bacteria, viruses, fungi and parasites stop responding to medicines designed to treat them. After the World Health Organization declared AMR one of the top 10 public health threats facing humanity, national action plans to tackle the threat were developed by more than 100 countries. Academics say the plans focus on designing policies to curb AMR and devising tools to implement the policies -- but they do not adequately factor in monitoring and evaluation. Mon, 05 Jun 2023 18:12:44 EDT //www.koonmotors.com/releases/2023/06/230605181244.htm //www.koonmotors.com/releases/2023/06/230605181002.htm Scientists have shown that a new targeted therapy drug can extend the amount of time people with a subtype of glioma are on treatment without their cancer worsening. The finding suggests a possible new treatment option for people with the slow-growing but deadly brain tumor. Mon, 05 Jun 2023 18:10:02 EDT //www.koonmotors.com/releases/2023/06/230605181002.htm //www.koonmotors.com/releases/2023/06/230602115106.htm Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles. There is no cure, and current treatments focus on reducing symptoms and providing supportive care. Researchers now show in an early clinical trial that the Parkinson's disease drug ropinirole is safe to use in ALS patients and delayed disease progression by 27.9 weeks on average. Fri, 02 Jun 2023 11:51:06 EDT //www.koonmotors.com/releases/2023/06/230602115106.htm //www.koonmotors.com/releases/2023/06/230601182921.htm The results of a new clinical trial suggest that the first drug therapy to slow the progression of nearsightedness in kids could be on the horizon. The three-year study found that a daily drop in each eye of a low dose of atropine, a drug used to dilate pupils, was better than a placebo at limiting eyeglass prescription changes and inhibiting elongation of the eye in nearsighted children aged 6 to 10. Thu, 01 Jun 2023 18:29:21 EDT //www.koonmotors.com/releases/2023/06/230601182921.htm //www.koonmotors.com/releases/2023/06/230601160147.htm Health professionals are in urgent need of new antibiotics to tackle resistant bacteria. Researchers have now modified the chemical structure of naturally occurring peptides to develop antimicrobial molecules that bind to novel targets in the bacteria's metabolism. Thu, 01 Jun 2023 16:01:47 EDT //www.koonmotors.com/releases/2023/06/230601160147.htm //www.koonmotors.com/releases/2023/06/230601160139.htm In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research. Thu, 01 Jun 2023 16:01:39 EDT //www.koonmotors.com/releases/2023/06/230601160139.htm //www.koonmotors.com/releases/2023/06/230601155927.htm Researchers have collaborated to refine a cell culture technology platform that grows genetically identical lung buds from human embryonic stem cells. Thu, 01 Jun 2023 15:59:27 EDT //www.koonmotors.com/releases/2023/06/230601155927.htm 计画ps://www.koonmotors.com/releases/2023/05/230531150050.htm Chemists add another powerful tool to their 'molecular editing' toolkit for crafting pharmaceuticals and other valuable compounds. Wed, 31 May 2023 15:00:50 EDT 计画ps://www.koonmotors.com/releases/2023/05/230531150050.htm 计画ps://www.koonmotors.com/releases/2023/05/230530174302.htm 虽然可以把年制药印第安纳州ustry to create medicines capable of treating or curing human disease, a new study suggests that using generative artificial intelligence could vastly accelerate the drug-development process. Tue, 30 May 2023 17:43:02 EDT 计画ps://www.koonmotors.com/releases/2023/05/230530174302.htm 计画ps://www.koonmotors.com/releases/2023/05/230530125408.htm Complicated, hard-to-heal wounds are a growing medical problem and there are currently only two drugs approved with proven efficacy. In a new study on humans, researchers show that treatment with a specific type of modified lactic acid bacteria works well and has a positive effect on the healing of wounds. Tue, 30 May 2023 12:54:08 EDT 计画ps://www.koonmotors.com/releases/2023/05/230530125408.htm 计画ps://www.koonmotors.com/releases/2023/05/230526142239.htm Researchers have developed a nanorobot system that targets fungal infections in the mouth. Fri, 26 May 2023 14:22:39 EDT 计画ps://www.koonmotors.com/releases/2023/05/230526142239.htm 计画ps://www.koonmotors.com/releases/2023/05/230526142234.htm The first protein-based nano-computing agent that functions as a circuit has been created. The milestone puts them one step closer to developing next-generation cell-based therapies to treat diseases like diabetes and cancer. Fri, 26 May 2023 14:22:34 EDT 计画ps://www.koonmotors.com/releases/2023/05/230526142234.htm 计画ps://www.koonmotors.com/releases/2023/05/230525141523.htm Using AI, researchers identified a new antibiotic that can kill Acinetobacter baumannii, a type of bacteria that is responsible for many drug-resistant infections. Thu, 25 May 2023 14:15:23 EDT 计画ps://www.koonmotors.com/releases/2023/05/230525141523.htm 计画ps://www.koonmotors.com/releases/2023/05/230525141418.htm Researchers say they have evidence that an experimental drug may prevent or slow vision loss in people with diabetes. The results are from a study that used mouse as well as human retinal organoids and eye cell lines. Thu, 25 May 2023 14:14:18 EDT 计画ps://www.koonmotors.com/releases/2023/05/230525141418.htm 计画ps://www.koonmotors.com/releases/2023/05/230525141412.htm Cancers often release molecules into the bloodstream that pathologically alter the liver, shifting it to an inflammatory state, causing fat buildup and impairing its normal detoxifying functions, according to a study from investigators at Weill Cornell Medicine. This discovery illuminates one of cancer's more insidious survival mechanisms and suggests the possibility of new tests and drugs for detecting and reversing this process. Thu, 25 May 2023 14:14:12 EDT 计画ps://www.koonmotors.com/releases/2023/05/230525141412.htm 计画ps://www.koonmotors.com/releases/2023/05/230525141321.htm A new tool which could help reduce the spread of antimicrobial resistance is showing early promise, through exploiting a bacterial immune system as a gene editing tool. Thu, 25 May 2023 14:13:21 EDT 计画ps://www.koonmotors.com/releases/2023/05/230525141321.htm 计画ps://www.koonmotors.com/releases/2023/05/230524181939.htm Engineers have designed a new class of 'microrobots' several times smaller than the width of a human hair that may be able to treat human illnesses like interstitial cystitis -- a painful bladder disease that affects millions of Americans. Wed, 24 May 2023 18:19:39 EDT 计画ps://www.koonmotors.com/releases/2023/05/230524181939.htm 计画ps://www.koonmotors.com/releases/2023/05/230524181935.htm A new study has shown that human T cells have an important role to play in controlling infection. Wed, 24 May 2023 18:19:35 EDT 计画ps://www.koonmotors.com/releases/2023/05/230524181935.htm 计画ps://www.koonmotors.com/releases/2023/05/230524181929.htm Tau protein is implicated in many neurogenerative diseases, including Alzheimer's. New findings point to a new potential drug target to slow the progress of the disease: the enzymes responsible for sulfation called heparan sulfate 3-O transferases. Wed, 24 May 2023 18:19:29 EDT 计画ps://www.koonmotors.com/releases/2023/05/230524181929.htm 计画ps://www.koonmotors.com/releases/2023/05/230524181908.htm Recent research has identified a new compound that can stimulate nerve regeneration after injury, as well as protect cardiac tissue from the sort of damage seen in heart attack. Wed, 24 May 2023 18:19:08 EDT 计画ps://www.koonmotors.com/releases/2023/05/230524181908.htm 计画ps://www.koonmotors.com/releases/2023/05/230523185024.htm Researchers have engineered bacteria to synthesize an amino acid that contains a rare functional group that others have shown to have implications in the regulation of our immune system. The researchers also taught a single bacterial strain to create the amino acid and place it at specific sites within target proteins. These findings provide a foundation for developing unique vaccines and immunotherapies in the future. Tue, 23 May 2023 18:50:24 EDT 计画ps://www.koonmotors.com/releases/2023/05/230523185024.htm 计画ps://www.koonmotors.com/releases/2023/05/230523123752.htm A global phase 3 clinical trial found that a year-long immunotherapy through a skin patch safely desensitized toddlers with peanut allergy, lowering the risk of a severe allergic reaction from accidental exposure. Tue, 23 May 2023 12:37:52 EDT 计画ps://www.koonmotors.com/releases/2023/05/230523123752.htm 计画ps://www.koonmotors.com/releases/2023/05/230522131403.htm Researchers synthesize fluorine-based compound via rapid biphasic (gas and liquid) mixing. Mon, 22 May 2023 13:14:03 EDT 计画ps://www.koonmotors.com/releases/2023/05/230522131403.htm 计画ps://www.koonmotors.com/releases/2023/05/230522131334.htm Every day, millions of cells die in our body. Other than generally assumed, cells do not simply burst at the end of their lives but rather, a specific protein serves as a breaking point for cell membrane rupture. Researchers have now been able to elucidate the exact mechanism at the atomic level. Mon, 22 May 2023 13:13:34 EDT 计画ps://www.koonmotors.com/releases/2023/05/230522131334.htm