//www.koonmotors.com/news/health_medicine/joint_pain/ Information on causes of joint pains and how to find relief. Read latest research on early lupus symptoms and Lyme disease symptoms, and unravel the mystery behind the common aches and pains of fibromyalgia. en-us Wed, 05 Jul 2023 22:45:53 EDT Wed, 05 Jul 2023 22:45:53 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/joint_pain/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/06/230627225150.htm Recurrent bouts of systemic lupus erythematosus, marked by the body's immune system attack of its own tissues, closely tracked with measureable upticks in growth in the gut of a certain species of bacteria. Tue, 27 Jun 2023 22:51:50 EDT //www.koonmotors.com/releases/2023/06/230627225150.htm //www.koonmotors.com/releases/2023/06/230622120855.htm New research has found that in a mouse model mimicking Alzheimer's Disease (AD) pain signals are not processed in the same way as in healthy mice. Thu, 22 Jun 2023 12:08:55 EDT //www.koonmotors.com/releases/2023/06/230622120855.htm //www.koonmotors.com/releases/2023/04/230421112640.htm A majority of parents of children diagnosed with Lyme disease reported that their kids recovered within six months of completing antibiotic treatment, according to a new study. The findings, based on Lyme disease treatment outcome data from 102 children in the United States, also revealed that a notably small percentage of children took longer than six months to recover and experienced a significant impact on their daily functioning. Fri, 21 Apr 2023 11:26:40 EDT //www.koonmotors.com/releases/2023/04/230421112640.htm //www.koonmotors.com/releases/2023/04/230405112151.htm Feeling like we have a degree of control makes us tolerate pain better. In the case of fibromyalgia, however, this simply doesn't work. A study provides clues as to why. Wed, 05 Apr 2023 11:21:51 EDT //www.koonmotors.com/releases/2023/04/230405112151.htm //www.koonmotors.com/releases/2023/03/230330172106.htm As tick season kicks in across the country, scientists have completed research that offers a promising lead in the fight against Lyme disease. Thu, 30 Mar 2023 17:21:06 EDT //www.koonmotors.com/releases/2023/03/230330172106.htm //www.koonmotors.com/releases/2023/03/230308112118.htm Scientists have made an important breakthrough in understanding what goes wrong in our bodies during the progression of inflammatory diseases and -- in doing so -- unearthed a potential new therapeutic target. The scientists have found that an enzyme called fumarate hydratase is repressed in macrophages, a frontline inflammatory cell type implicated in a range of diseases including lupus, arthritis, sepsis and COVID-19. Wed, 08 Mar 2023 11:21:18 EST //www.koonmotors.com/releases/2023/03/230308112118.htm //www.koonmotors.com/releases/2023/02/230201195336.htm A pair of researchers reports the success of their new, at-home method for early diagnosis and monitoring of lupus nephritis. or inflammation of the kidneys, one of the most severe complications for patients with systemic lupus erythematosus, known as lupus. Wed, 01 Feb 2023 19:53:36 EST //www.koonmotors.com/releases/2023/02/230201195336.htm //www.koonmotors.com/releases/2023/01/230126100201.htm Scientists have discovered the role of microRNA on inflammation in lupus disease. They identified the microRNAs that are downregulated in the disease and how they converge to cause the disease. Thu, 26 Jan 2023 10:02:01 EST //www.koonmotors.com/releases/2023/01/230126100201.htm //www.koonmotors.com/releases/2023/01/230113145351.htm Targeting iron metabolism in immune system cells may offer a new approach for treating systemic lupus erythematosus (SLE) -- the most common form of the chronic autoimmune disease lupus. A multidisciplinary team of investigators has discovered that blocking an iron uptake receptor reduces disease pathology and promotes the activity of anti-inflammatory regulatory T cells in a mouse model of SLE. Fri, 13 Jan 2023 14:53:51 EST //www.koonmotors.com/releases/2023/01/230113145351.htm //www.koonmotors.com/releases/2022/12/221208114741.htm Commonly used drugs that reduce joint inflammation in patients with rheumatoid arthritis also reduce vascular inflammation and cardiovascular risk, finds a new study. Thu, 08 Dec 2022 11:47:41 EST //www.koonmotors.com/releases/2022/12/221208114741.htm //www.koonmotors.com/releases/2022/11/221123125121.htm Investigators have reported highly promising early results for CAR T therapy in a small set of patients with the autoimmune disease lupus. Wed, 23 Nov 2022 12:51:21 EST //www.koonmotors.com/releases/2022/11/221123125121.htm //www.koonmotors.com/releases/2022/11/221118095415.htm So far, there no uniform guidelines have existed for the treatment of arthritis of the jaw, a potentially debilitating consequence of juvenile arthritis. Fri, 18 Nov 2022 09:54:15 EST //www.koonmotors.com/releases/2022/11/221118095415.htm //www.koonmotors.com/releases/2022/11/221115113916.htm Researchers have identified 35 genes that are particularly highly expressed in people with long-term Lyme disease. These genes could potentially be used as biomarkers to diagnose patients with the condition, which is otherwise difficult to diagnose and treat. The findings may also lead to new therapeutic targets. Tue, 15 Nov 2022 11:39:16 EST //www.koonmotors.com/releases/2022/11/221115113916.htm //www.koonmotors.com/releases/2022/11/221104093255.htm The number of new diagnoses of rheumatoid arthritis fell by 20 percent in the first year of the COVID-19 pandemic, new research suggests. Fri, 04 Nov 2022 09:32:55 EDT //www.koonmotors.com/releases/2022/11/221104093255.htm //www.koonmotors.com/releases/2022/11/221103140801.htm Some genetic variants may put people at risk of autoimmune diseases while conferring protection against the outcome of viral infection. A new study suggests that genetic predisposition for systemic lupus erythematosus (SLE) may be protective against severe COVID-19 infection. Thu, 03 Nov 2022 14:08:01 EDT //www.koonmotors.com/releases/2022/11/221103140801.htm //www.koonmotors.com/releases/2022/10/221026153655.htm In a study using specialized imaging techniques, researchers report distinctive changes in the 'white matter' and other brain tissue physiology of those with post-treatment Lyme disease, a condition affecting 10% to 20% of the nearly half a million Americans who contract Lyme disease annually. Wed, 26 Oct 2022 15:36:55 EDT //www.koonmotors.com/releases/2022/10/221026153655.htm //www.koonmotors.com/releases/2022/09/220928094611.htm Hitherto, scientists have not fully understood why ticks are such dangerous disease vectors. A research team now shows that tick saliva inhibits the skin's defense function, thereby increasing the risk of diseases such as tick-borne encephalitis (TBE) or Lyme disease. 结婚,2022年9月28日09:46:11 EDT //www.koonmotors.com/releases/2022/09/220928094611.htm //www.koonmotors.com/releases/2022/09/220908112326.htm A team of engineers and doctors has designed a unique 3D-printed light-sensing medical device that could help millions of people worldwide with lupus and other light-sensitive diseases. Thu, 08 Sep 2022 11:23:26 EDT //www.koonmotors.com/releases/2022/09/220908112326.htm //www.koonmotors.com/releases/2022/09/220908100052.htm Scientists have identified a protein known as sulfatase-2 that plays a critical role in the damage caused by rheumatoid arthritis. The researchers' discovery sheds new light on the molecular processes that drive inflammation seen in rheumatoid arthritis. It could also someday lead to improved treatment of the disease, which currently has no cure. Thu, 08 Sep 2022 10:00:52 EDT //www.koonmotors.com/releases/2022/09/220908100052.htm //www.koonmotors.com/releases/2022/08/220828150105.htm An international research team presents the outcome of a thorough epidemiological investigation into possible links between nineteen of the most common autoimmune disorders and cardiovascular disease. The results of the study show that patients with autoimmune disease have a substantially higher risk (between 1.4 and 3.6 times depending on which autoimmune condition) of developing cardiovascular disease than people without an autoimmune disorder. Sun, 28 Aug 2022 15:01:05 EDT //www.koonmotors.com/releases/2022/08/220828150105.htm //www.koonmotors.com/releases/2022/07/220714103012.htm A new study finds that technology through video game-based cognitive therapy improves attention and executive functioning in patients with systemic lupus erythematosus (SLE). Thu, 14 Jul 2022 10:30:12 EDT //www.koonmotors.com/releases/2022/07/220714103012.htm //www.koonmotors.com/releases/2022/07/220713143955.htm Researchers describe the biochemical pathway that results in the generation of oxidized mitochondrial DNA, how it is expelled by mitochondria and how it triggers the complex and destructive inflammatory response that follows. Wed, 13 Jul 2022 14:39:55 EDT //www.koonmotors.com/releases/2022/07/220713143955.htm //www.koonmotors.com/releases/2022/07/220711111834.htm 一种新型分子pathway involving cell signalling proteins in the brain may explain how stress affects neuropsychiatric lupus with diffuse neuropsychological manifestations. Mon, 11 Jul 2022 11:18:34 EDT //www.koonmotors.com/releases/2022/07/220711111834.htm //www.koonmotors.com/releases/2022/06/220602121433.htm 国家专家在系统性红斑狼疮,or lupus, has identified biomarkers for heart disease and for children with lupus nephritis. Thu, 02 Jun 2022 12:14:33 EDT //www.koonmotors.com/releases/2022/06/220602121433.htm //www.koonmotors.com/releases/2022/05/220517112216.htm Adenosine triphosphate (ATP) secreted from sensory neuron-interneuron crosstalk is key to the spreading of inflammation across joints, acting as a neurotransmitter and inflammation enhancer. Tue, 17 May 2022 11:22:16 EDT //www.koonmotors.com/releases/2022/05/220517112216.htm //www.koonmotors.com/releases/2022/05/220503083003.htm A new study finds that the normal-appearing skin of lupus patients contains the same inflammatory signals that are detected when the skin develops a rash, sometimes at even higher levels. Researchers say immune cells undergo an inflammatory transformation that primes the skin without rashes for disease flares. Tue, 03 May 2022 08:30:03 EDT //www.koonmotors.com/releases/2022/05/220503083003.htm //www.koonmotors.com/releases/2022/04/220427115727.htm 一个国际研究团队已经标识符d DNA mutations in a gene that senses viral RNA, as a cause of the autoimmune disease lupus, with the finding paving the way for the development of new treatments. Wed, 27 Apr 2022 11:57:27 EDT //www.koonmotors.com/releases/2022/04/220427115727.htm //www.koonmotors.com/releases/2022/03/220322111239.htm Antiphospholipid syndrome (APS) is rare in children and known to cause inflammation and recurring, potentially fatal, blood clots. Researchers found that two-thirds of children with the autoimmune disease experienced additional symptoms not formally associated with APS, including low platelet counts, hemolytic anemia and livedo reticularis, a rash indicating abnormal blood flow to the skin. Investigators say the findings underscore the importance of creating pediatric-specific criteria for the diagnosis of APS. Tue, 22 Mar 2022 11:12:39 EDT //www.koonmotors.com/releases/2022/03/220322111239.htm //www.koonmotors.com/releases/2022/02/220217141203.htm Analyzing the brain changes that occur in the first stages of juvenile fibromyalgia could help to better understand the pathophysiology of this syndrome. Thu, 17 Feb 2022 14:12:03 EST //www.koonmotors.com/releases/2022/02/220217141203.htm //www.koonmotors.com/releases/2022/02/220209155008.htm An expert in autoimmune diseases and systemic lupus erythematosus has identified potential biomarkers for neuropsychiatric symptoms of lupus after conducting a large-scale protein study. Wed, 09 Feb 2022 15:50:08 EST //www.koonmotors.com/releases/2022/02/220209155008.htm //www.koonmotors.com/releases/2022/01/220104123556.htm 研究人员发现,有一种of autoimmune disease can lead to another. Tue, 04 Jan 2022 12:35:56 EST //www.koonmotors.com/releases/2022/01/220104123556.htm //www.koonmotors.com/releases/2021/12/211208094926.htm Lupus, an autoimmune disease, and macular degeneration, a leading cause of vision loss, share a common contributor to harmful inflammation, researchers found. Wed, 08 Dec 2021 09:49:26 EST //www.koonmotors.com/releases/2021/12/211208094926.htm //www.koonmotors.com/releases/2021/11/211130112520.htm Researchers have discovered that the bacterium that causes Lyme disease has a highly unusual modification in its protective molecular bag -- its peptidoglycan, which is common to all bacteria. 星期二,2021年11月30日11:25:20 EST //www.koonmotors.com/releases/2021/11/211130112520.htm //www.koonmotors.com/releases/2021/11/211117100053.htm Exercise increases the body's own cannabis-like substances, which in turn helps reduce inflammation and could potentially help treat certain conditions such as arthritis, cancer and heart disease. Wed, 17 Nov 2021 10:00:53 EST //www.koonmotors.com/releases/2021/11/211117100053.htm //www.koonmotors.com/releases/2021/10/211015133229.htm Researchers can find signs of whether a person is on the way to developing the disease Lupus -- or is already ill. The revolutionary technique can be an important tool for diagnosing more autoimmune diseases. Fri, 15 Oct 2021 13:32:29 EDT //www.koonmotors.com/releases/2021/10/211015133229.htm //www.koonmotors.com/releases/2021/10/211014131149.htm Researchers have described a new antibiotic that appears to have the potential to cure Lyme disease. Thu, 14 Oct 2021 13:11:49 EDT //www.koonmotors.com/releases/2021/10/211014131149.htm //www.koonmotors.com/releases/2021/08/210816161346.htm A potential biomarker predicting severity of heart disease in African American lupus patients was identified in a study conducted by a team of researchers. Mon, 16 Aug 2021 16:13:46 EDT //www.koonmotors.com/releases/2021/08/210816161346.htm //www.koonmotors.com/releases/2021/08/210812135922.htm The autoimmune disease lupus may be triggered by a defective process in the development of red blood cells (RBCs), according to a new study. The discovery could lead to new methods for classifying and treating patients with this disease. Thu, 12 Aug 2021 13:59:22 EDT //www.koonmotors.com/releases/2021/08/210812135922.htm //www.koonmotors.com/releases/2021/08/210811131528.htm A recent study shows the association between bank vole abundance variations and the incidence of Lyme Borreliosis and Puumala hantavirus infections. The study showed that the abundance variations of the reservoir hosts of wildlife originated pathogens have importance in estimating the risks these pathogens pose to humans. The results of the work can be taken into account in the risk communication by health authorities. Wed, 11 Aug 2021 13:15:28 EDT //www.koonmotors.com/releases/2021/08/210811131528.htm //www.koonmotors.com/releases/2021/08/210811113136.htm A new study reports that patients hospitalized with Lyme disease had a 28 percent higher rate of mental disorders and were twice as likely to attempt suicide. Physicians and patients should be aware of the potential for psychiatric symptoms post-Lyme infection, particularly during the first year after diagnosis. Wed, 11 Aug 2021 11:31:36 EDT //www.koonmotors.com/releases/2021/08/210811113136.htm //www.koonmotors.com/releases/2021/07/210701120703.htm New research has shown that many of the symptoms in fibromyalgia syndrome (FMS) are caused by antibodies that increase the activity of pain-sensing nerves throughout the body. The results show that fibromyalgia is a disease of the immune system, rather than the currently held view that it originates in the brain. Thu, 01 Jul 2021 12:07:03 EDT //www.koonmotors.com/releases/2021/07/210701120703.htm //www.koonmotors.com/releases/2021/06/210624121715.htm As the ravages of the opioid epidemic lead many to avoid these powerful painkillers, a significant number of people with fibromyalgia are finding an effective replacement in CBD-containing products, finds a new study. Thu, 24 Jun 2021 12:17:15 EDT //www.koonmotors.com/releases/2021/06/210624121715.htm //www.koonmotors.com/releases/2021/05/210513142419.htm Epidemic. Pandemic. These terms have become second nature to us, popping up in everyday conversation, and for good reason -- COVID-19 is the latest pandemic to pose a threat to humanity. But in recent months, far less attention has been paid to another widely spread problem that has been proliferating since the late 1970s: Lyme disease. Thu, 13 May 2021 14:24:19 EDT //www.koonmotors.com/releases/2021/05/210513142419.htm //www.koonmotors.com/releases/2021/03/210316132059.htm The findings of a recent analysis suggest that ecosystems suitable for harboring ticks that carry debilitating Lyme disease could be more widespread than previously thought in California, Oregon and Washington. Tue, 16 Mar 2021 13:20:59 EDT //www.koonmotors.com/releases/2021/03/210316132059.htm //www.koonmotors.com/releases/2021/02/210224090634.htm Rheumatoid arthritis is a chronic inflammatory disorder marked by joint pain, swelling and damage. Although medications, such as steroids, anti-inflammatory drugs and immunosuppressants, can help slow joint destruction and relieve pain, they have side effects and aren't completely successful. Now, researchers have developed magnesium-based micromotors propelled by hydrogen bubbles, which improved rheumatoid arthritis symptoms when injected into the joints of rats. Wed, 24 Feb 2021 09:06:34 EST //www.koonmotors.com/releases/2021/02/210224090634.htm //www.koonmotors.com/releases/2021/02/210202113903.htm Autoimmune diseases, in which the body's own immune system attacks healthy tissue, can be life-threatening and can impact all organs. A research team has now found a possible cause for these self-destructive immune system attacks: a hyperactive RANK protein on the surface of B cells. The research opens the door to new therapeutic possibilities. Tue, 02 Feb 2021 11:39:03 EST //www.koonmotors.com/releases/2021/02/210202113903.htm //www.koonmotors.com/releases/2021/01/210121163132.htm A new collaborative study reveals unexpected insights into how skin exposure to ultraviolet light can worsen clinical symptoms in autoimmune diseases such as lupus. Thu, 21 Jan 2021 16:31:32 EST //www.koonmotors.com/releases/2021/01/210121163132.htm //www.koonmotors.com/releases/2021/01/210106133030.htm The main bioactive compound of ginger root lowers autoantibody production and helps halt disease progression in mice with antiphospholipid syndrome and lupus. Wed, 06 Jan 2021 13:30:30 EST //www.koonmotors.com/releases/2021/01/210106133030.htm //www.koonmotors.com/releases/2020/12/201222192959.htm By drawing from decades of studies, scientists created a timeline marking the arrival of black-legged ticks, also known as deer ticks, in hundreds of counties across 10 Midwestern states. They used these data - along with an analysis of county-level landscape features associated with the spread of ticks - to build a model that can predict where ticks are likely to appear in future years. Tue, 22 Dec 2020 19:29:59 EST //www.koonmotors.com/releases/2020/12/201222192959.htm //www.koonmotors.com/releases/2020/12/201210112122.htm One reason ticks spread Lyme disease so well goes back to a unique evolutionary event. Researchers discovered that an antibacterial enzyme in ticks, Dae2, protects them from bacteria found on human skin, while still allowing them to harbor Borrelia burgdorferi, the bacterium that causes Lyme disease. Ticks acquired the gene for this enzyme 40 million years ago from an unknown species of ancient bacteria. Thu, 10 Dec 2020 11:21:22 EST //www.koonmotors.com/releases/2020/12/201210112122.htm //www.koonmotors.com/releases/2020/11/201116075724.htm A novel outpatient procedure offers lasting pain relief for patients suffering from moderate to severe arthritis in their hip and shoulder joints. 星期一,2020年11月16日07:57:24 EST //www.koonmotors.com/releases/2020/11/201116075724.htm //www.koonmotors.com/releases/2020/11/201112134626.htm A collaborative team of scientists has pinpointed two new potential therapeutic targets for rheumatoid arthritis - a painful inflammatory disease that affects an estimated 350 million people worldwide. Thu, 12 Nov 2020 13:46:26 EST //www.koonmotors.com/releases/2020/11/201112134626.htm //www.koonmotors.com/releases/2020/11/201111144333.htm Researchers have discovered a protein that helps protect hosts from infection with the tick-borne spirochete that causes Lyme Disease, a finding that may help diagnose and treat this infection. Wed, 11 Nov 2020 14:43:33 EST //www.koonmotors.com/releases/2020/11/201111144333.htm //www.koonmotors.com/releases/2020/11/201106103103.htm A new study shows that patients with rheumatic diseases across Africa, Southeast Asia, the Americas and Europe had trouble filling their prescriptions of antimalarial drugs, including hydroxychloroquine, during the 2020 global coronavirus pandemic, when antimalarials were touted as a possible COVID-19 treatment. Patients who could not access their antimalarial drugs faced worse physical and mental health outcomes as a result. Fri, 06 Nov 2020 10:31:03 EST //www.koonmotors.com/releases/2020/11/201106103103.htm //www.koonmotors.com/releases/2020/11/201106095654.htm New research shows that use of hydroxychloroquine, a generic drug, does not cause any significant differences in QTc length or prolonged QTc, key measures of heart rate, in people with rheumatoid arthritis (RA) or systemic lupus erythematosus. Fri, 06 Nov 2020 09:56:54 EST //www.koonmotors.com/releases/2020/11/201106095654.htm //www.koonmotors.com/releases/2020/10/201007085632.htm A new study has examined patterns of 24-hour physical activity and sleep among patients with rheumatoid arthritis, lupus, and knee osteoarthritis. Wed, 07 Oct 2020 08:56:32 EDT //www.koonmotors.com/releases/2020/10/201007085632.htm //www.koonmotors.com/releases/2020/09/200922144327.htm While disease activity improves over time for most rheumatoid arthritis (RA) patients, long-term outcomes only improve in RA patients with autoantibodies, according to a new study. The findings add to a growing body of evidence that RA with and without autoantibodies are two distinct conditions. Tue, 22 Sep 2020 14:43:27 EDT //www.koonmotors.com/releases/2020/09/200922144327.htm //www.koonmotors.com/releases/2020/09/200922102422.htm Researchers have successfully treated two patients with the autoimmune disease systemic lupus erythematosus. Using daratumumab, a monoclonal antibody which targets specific immune cells known as plasma cells, the researchers were able to modulate the abnormal immunological memory processes found in these patients. Treatment induced sustainable clinical responses and resulted in a reduction in systemic inflammation. Tue, 22 Sep 2020 10:24:22 EDT //www.koonmotors.com/releases/2020/09/200922102422.htm //www.koonmotors.com/releases/2020/09/200921083707.htm The strongest evidence yet of a single cause for psoriatic arthritis has been discovered by researchers. The disease may be activated by the same trigger in different patients which, if identified, could move towards creating therapies that would prevent psoriatic arthritis, and potentially providing a cure. 星期一,2020年9月21日08:37:07美国东部时间 //www.koonmotors.com/releases/2020/09/200921083707.htm //www.koonmotors.com/releases/2020/09/200910090046.htm Previous research has demonstrated a variety of health benefits associated with the Mediterranean diet, which is rich in olive oil, cereals, fruit and vegetables, fish, and a moderate amount of dairy, meat, and wine. Now results suggest that the diet may also help prevent rheumatoid arthritis in individuals who smoke or used to smoke. Thu, 10 Sep 2020 09:00:46 EDT //www.koonmotors.com/releases/2020/09/200910090046.htm