//www.koonmotors.com/news/health_medicine/bone_and_spine/ Read the latest medical research on healthy bone and spine development. Find out about spinal problems and new treatment options. en-us Wed, 06 Sep 2023 14:48:17 EDT Wed, 06 Sep 2023 14:48:17 EDT 60 //www.koonmotors.com/images/scidaily-logo-rss.png//www.koonmotors.com/news/health_medicine/bone_and_spine/ For more science news, visit ScienceDaily. //www.koonmotors.com/releases/2023/08/230818004425.htm Amyotrophic lateral sclerosis (ALS) is a widespread neurodegenerative disease caused by the loss of neurons that control movement. Although abnormal accumulation of proteins called TDP-43 accompanies ALS, its role in disease progression is not well understood. Recently, using novel mouse models of ALS, researchers have identified the neurological spreading patterns through which TDP-43 perpetuates the degeneration of the movement-related neural circuitry. Fri, 18 Aug 2023 00:44:25 EDT //www.koonmotors.com/releases/2023/08/230818004425.htm //www.koonmotors.com/releases/2023/08/230816114119.htm A research team has recently made a significant advancement in spinal cord injury treatment by using genetically modified human neural stem cells (hNSCs). They found that specifically modulating a gene expression to a certain level in hNSCs can effectively promote the reconstruction of damaged neural circuits and restore locomotor functions, offering great potential for new therapeutic opportunities for patients with spinal cord injury. Wed, 16 Aug 2023 11:41:19 EDT //www.koonmotors.com/releases/2023/08/230816114119.htm //www.koonmotors.com/releases/2023/08/230810110422.htm New research has demonstrated the safety and tolerability of a new drug treatment designed as a therapeutic intervention for spinal cord injury (SCI). Thu, 10 Aug 2023 11:04:22 EDT //www.koonmotors.com/releases/2023/08/230810110422.htm //www.koonmotors.com/releases/2023/08/230809164732.htm A study shows new steps toward more patients getting gene therapy. Wed, 09 Aug 2023 16:47:32 EDT //www.koonmotors.com/releases/2023/08/230809164732.htm //www.koonmotors.com/releases/2023/08/230807164413.htm Tumor cells are known to be fickle sleeper agents, often lying dormant in distant tissues for years before reactivating and forming metastasis. Numerous factors have been studied to understand why the activation occurs, from cells and molecules to other components in the so-called tissue microenvironment. Mon, 07 Aug 2023 16:44:13 EDT //www.koonmotors.com/releases/2023/08/230807164413.htm //www.koonmotors.com/releases/2023/08/230803112943.htm The researchers showed how bone erosion caused by cholesteatoma occurs. This study showed that a subset of cells called osteoclastogenic fibroblasts expresses a protein, activin A, which causes the breakdown of the bones. Because of this discovery, novel medical treatments can be developed as first-line management for cholesteatomas. Thu, 03 Aug 2023 11:29:43 EDT //www.koonmotors.com/releases/2023/08/230803112943.htm //www.koonmotors.com/releases/2023/07/230725123125.htm Researchers have found that bone repair can be improved in mice with large bone lesions by injecting a combination of RNA encoding two different proteins. Their technique is a promising candidate for clinical use. This study provides new hope for patients with large bone lesions as a result of injury or surgery, in whom bone repair is often difficult to achieve. Tue, 25 Jul 2023 12:31:25 EDT //www.koonmotors.com/releases/2023/07/230725123125.htm //www.koonmotors.com/releases/2023/07/230719112646.htm As life expectancy increases worldwide, age-associated diseases such as osteoporosis are having an increasing impact. Although early detection could help physicians intervene as soon as possible -- when treatment might offer the greatest benefit -- this type of detection is not yet possible with current osteoporosis diagnostic tests. Now, researchers have developed a biosensor that could someday help identify those most at risk for osteoporosis using less than a drop of blood. Wed, 19 Jul 2023 11:26:46 EDT //www.koonmotors.com/releases/2023/07/230719112646.htm //www.koonmotors.com/releases/2023/07/230718164245.htm 路易是第二个最常见的neurod身体疾病egenerative disease after Alzheimer's disease. A research group has now shown that the disease can be detected before symptoms appear, using a spinal fluid test. Researchers also demonstrate that reduced sense of smell is strongly linked to Lewy body disease even before other clear symptoms have developed. Tue, 18 Jul 2023 16:42:45 EDT //www.koonmotors.com/releases/2023/07/230718164245.htm //www.koonmotors.com/releases/2023/07/230717115723.htm Common bone density scans can detect a predictor of cardiovascular health risk -- a process which can now be done a LOT faster. Mon, 17 Jul 2023 11:57:23 EDT //www.koonmotors.com/releases/2023/07/230717115723.htm //www.koonmotors.com/releases/2023/06/230622142348.htm Clinicians have a new standard for graft-versus-host disease (GVHD) prevention after allogeneic hematopoietic stem cell transplantation, according to results from a phase III study. The new standard is more effective at preventing GVHD and came with less side effects, compared with the current gold standard. Thu, 22 Jun 2023 14:23:48 EDT //www.koonmotors.com/releases/2023/06/230622142348.htm //www.koonmotors.com/releases/2023/06/230622120855.htm New research has found that in a mouse model mimicking Alzheimer's Disease (AD) pain signals are not processed in the same way as in healthy mice. Thu, 22 Jun 2023 12:08:55 EDT //www.koonmotors.com/releases/2023/06/230622120855.htm //www.koonmotors.com/releases/2023/06/230621121030.htm A gel that combines both stiffness and toughness is a step forward in the bid to create biodegradable implants for joint injuries, according to new research. Mimicking articular cartilage, found in our knee and hip joints, is challenging. This cartilage is key to smooth joint movement, and damage to it can cause pain, reduce function, and lead to arthritis. One potential solution is to implant artificial scaffolds made of proteins that help the cartilage regenerate itself as the scaffold biodegrades. How well the cartilage regenerates is linked to how well a scaffold can mimic the biological properties of cartilage, and to date, researchers have struggled to combine the seemingly incompatible properties of stiffness and toughness. Now, new research outlines a method to marry these properties in a biodegradable gel. Wed, 21 Jun 2023 12:10:30 EDT //www.koonmotors.com/releases/2023/06/230621121030.htm //www.koonmotors.com/releases/2023/05/230525141244.htm The mental distress of cognitive dissonance -- encountering information that conflicts with how we act or what we believe -- can lead to added pressure on the neck and low back during lifting and lowering tasks, new research suggests. Thu, 25 May 2023 14:12:44 EDT //www.koonmotors.com/releases/2023/05/230525141244.htm //www.koonmotors.com/releases/2023/05/230504111839.htm Neuropathic pain -- abnormal hypersensitivity to stimuli -- is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV. Researchers report that a mechanism involving the enzyme Tiam1 in dorsal horn excitatory neurons of the spinal cord both initiates and maintains neuropathic pain. Moreover, they show that targeting spinal Tiam1 with anti-sense oligonucleotides injected into the cerebrospinal fluid effectively alleviated neuropathic pain hypersensitivity. Thu, 04 May 2023 11:18:39 EDT //www.koonmotors.com/releases/2023/05/230504111839.htm //www.koonmotors.com/releases/2023/04/230420135317.htm 调查人员正在开发一种新的治疗方法amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using engineered stem cells that may eventually lead to personalized treatments. Thu, 20 Apr 2023 13:53:17 EDT //www.koonmotors.com/releases/2023/04/230420135317.htm //www.koonmotors.com/releases/2023/04/230419125102.htm Scientists have pinpointed a key driver of low bone density, a discovery that may lead to improved treatments with fewer side effects for women with osteoporosis. The findings reveal that loss of an epigenetic modulator, KDM5C, preserves bone mass in mice. KDM5C works by altering epigenetic 'marks,' which are akin to 'on' and 'off' switches that ensure the instructions written in DNA are used at the right time and in the right place. Wed, 19 Apr 2023 12:51:02 EDT //www.koonmotors.com/releases/2023/04/230419125102.htm //www.koonmotors.com/releases/2023/04/230419125058.htm The bone density of astronauts -- of both the human and rodent variety -- decreases in space. Researchers report that changes to the gut microbiomes of space travelers might be associated with this bone loss. Rodents that spent a month or more on the International Space Station had altered and more diverse microbiomes, and the bacterial species that bloomed in space may have contributed to the increased production of molecules that are known to influence the bone remodeling process. Wed, 19 Apr 2023 12:50:58 EDT //www.koonmotors.com/releases/2023/04/230419125058.htm //www.koonmotors.com/releases/2023/04/230414113455.htm Young babies and newborn mice can naturally heal damage to the bones that form the top of the skull, but this ability is lost in adults. Researchers developed a novel approach that promoted bone regeneration in mice without implantation of bone tissue or biomaterials. Fri, 14 Apr 2023 11:34:55 EDT //www.koonmotors.com/releases/2023/04/230414113455.htm //www.koonmotors.com/releases/2023/03/230322190844.htm People who have low bone density may have an increased risk of developing dementia compared to people who have higher bone density. The study does not prove that low bone density causes dementia. It only shows an association. Wed, 22 Mar 2023 19:08:44 EDT //www.koonmotors.com/releases/2023/03/230322190844.htm //www.koonmotors.com/releases/2023/03/230321112627.htm Scientists have created wearable microscopes to enable unprecedented insight into the signaling patterns that occur within the spinal cords of mice. This technological advancement will help researchers better understand the neural basis of sensations and movement in healthy and disease contexts, such as chronic pain, itch, amyotrophic lateral sclerosis (ALS), or multiple sclerosis (MS). Tue, 21 Mar 2023 11:26:27 EDT //www.koonmotors.com/releases/2023/03/230321112627.htm //www.koonmotors.com/releases/2023/03/230320143746.htm Genes long known to control the formation of bones before birth also control bone healing later in life, a new study found. Mon, 20 Mar 2023 14:37:46 EDT //www.koonmotors.com/releases/2023/03/230320143746.htm //www.koonmotors.com/releases/2023/03/230313215106.htm Scientists have developed an osteogenic barrier coating material that maximizes the effect of guided bone regeneration (GBR) for implant placements. Mon, 13 Mar 2023 21:51:06 EDT //www.koonmotors.com/releases/2023/03/230313215106.htm //www.koonmotors.com/releases/2023/03/230308084406.htm People with chronic back pain may turn to spinal cord stimulation to ease their pain, but a Cochrane Review found no sustained benefits to the surgery that outweigh the costs and risks. Wed, 08 Mar 2023 08:44:06 EST //www.koonmotors.com/releases/2023/03/230308084406.htm //www.koonmotors.com/releases/2023/02/230223132816.htm A new study shows fasting can trigger a negative effect on fighting infection on a cellular level in mouse models. Thu, 23 Feb 2023 13:28:16 EST //www.koonmotors.com/releases/2023/02/230223132816.htm //www.koonmotors.com/releases/2023/02/230221132129.htm Elevated levels of air pollutants are associated with bone damage among postmenopausal women, according to new research. The effects were most evident on the lumbar spine, with nitrous oxides twice as damaging to the area than seen with normal aging. Tue, 21 Feb 2023 13:21:29 EST //www.koonmotors.com/releases/2023/02/230221132129.htm //www.koonmotors.com/releases/2023/02/230213134652.htm Millions of endurance runners use footwear that has an embedded carbon fiber plate (CFP) in the midsole. While the performance benefits that carbon fiber plate footwear offers have been well documented, little has been published about running injuries related to use of this footwear. In a current opinion piece, authors describe five cases in which runners using carbon fiber plate footwear sustained bone stress injuries. Mon, 13 Feb 2023 13:46:52 EST //www.koonmotors.com/releases/2023/02/230213134652.htm //www.koonmotors.com/releases/2023/02/230209094140.htm DNA can help to stimulate bone healing in a localized and targeted manner, for example after a complicated fracture or after severe tissue loss following surgery. Scientists have developed a new process in which they coat implant materials with a gene-activated biomaterial that induces stem cells to produce bone tissue. Thu, 09 Feb 2023 09:41:40 EST //www.koonmotors.com/releases/2023/02/230209094140.htm //www.koonmotors.com/releases/2023/02/230206170612.htm Young blood may be an elixir for older bodies, rejuvenating aging hearts, muscles, and brains. But how can old blood become young again? Stem cell scientists may have found a way. Mon, 06 Feb 2023 17:06:12 EST //www.koonmotors.com/releases/2023/02/230206170612.htm //www.koonmotors.com/releases/2023/01/230111104303.htm How cells shape complex tissues and organs during embryo development, which makes us what we are, has many mysteries. New research has examined one such process which leads to the formation of vertebral column or spinal column. If this process is disrupted, it results in a birth defect called congenital scoliosis, or curvature of the spine. The research not only advanced understanding of how complex biological tissues form, but it could also lead to possible treatments for scoliosis in the future. Wed, 11 Jan 2023 10:43:03 EST //www.koonmotors.com/releases/2023/01/230111104303.htm //www.koonmotors.com/releases/2023/01/230109191639.htm Cats always land on their feet, but what makes them so agile? Their unique sense of balance has more in common with humans than it may appear. Researchers are studying cat locomotion to better understand how the spinal cord works to help humans with partial spinal cord damage walk and maintain balance. Mon, 09 Jan 2023 19:16:39 EST //www.koonmotors.com/releases/2023/01/230109191639.htm //www.koonmotors.com/releases/2022/12/221222101006.htm A team of medical researchers has analyzed damage by focused high energetic X-rays in bone samples from fish and mammals at BESSY II. With a combination of microscopy techniques, the scientists could document the destruction of collagen fibers induced by electrons emitted from the mineral crystals. X-ray methods might impact bone samples when measured for a long time they conclude. Thu, 22 Dec 2022 10:10:06 EST //www.koonmotors.com/releases/2022/12/221222101006.htm //www.koonmotors.com/releases/2022/12/221221135537.htm What keeps bones able to remodel themselves and stay healthy? A team has discovered clues to the key function of non-collagen protein compounds and how they help bone cells react to external load. The scientists used fish models to examine bone samples with and without bone cells to elucidate differences in microstructures and the incorporation of water. Using 3D neutron tomography they succeeded for the first time in precisely measuring the water diffusion across bone material -- with a surprising result. 结婚,2022年12月21日13:55:37 EST //www.koonmotors.com/releases/2022/12/221221135537.htm //www.koonmotors.com/releases/2022/12/221221121312.htm Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels. But what prevents neurons and vascular cells from getting in each other's way as they grow? Researchers have identified a mechanism that takes care of this. Wed, 21 Dec 2022 12:13:12 EST //www.koonmotors.com/releases/2022/12/221221121312.htm //www.koonmotors.com/releases/2022/12/221220113003.htm In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts. An agent that inhibits the activity of this enzyme reduced cancer-related bone loss and the number of bone metastases in multiple myeloma and in lung and breast cancer models in mice. Tue, 20 Dec 2022 11:30:03 EST //www.koonmotors.com/releases/2022/12/221220113003.htm //www.koonmotors.com/releases/2022/12/221219094912.htm An animal experiment demonstrates what big data analysis previously indicated: high doses of statins likely increase osteoporosis risk. Mon, 19 Dec 2022 09:49:12 EST //www.koonmotors.com/releases/2022/12/221219094912.htm //www.koonmotors.com/releases/2022/12/221209153110.htm Researchers have developed a new strontium-loaded scaffold that can be personalized to fit any size dental implant and could help improve healing and tissue attachment in patients. Fri, 09 Dec 2022 15:31:10 EST //www.koonmotors.com/releases/2022/12/221209153110.htm //www.koonmotors.com/releases/2022/12/221206204809.htm Researchers identified an oral compound that influences components of the parathyroid hormone signaling pathway to increase bone formation and bone mass in mice. Tue, 06 Dec 2022 20:48:09 EST //www.koonmotors.com/releases/2022/12/221206204809.htm //www.koonmotors.com/releases/2022/11/221130151516.htm Cartilage degeneration and injuries affect 350 million people worldwide. Patients with these conditions experience increased pain and discomfort over time. However, an exciting breakthrough in tissue regeneration research offers the promise of meaningful relief. Wed, 30 Nov 2022 15:15:16 EST //www.koonmotors.com/releases/2022/11/221130151516.htm //www.koonmotors.com/releases/2022/11/221129134405.htm Unique new material has shown significant promise in the treatment of spinal cord injury. The new hybrid biomaterials, in the form of nanoparticles and building on existing practice in the tissue engineering field, were successfully synthesized to promote repair and regeneration following spinal cord injury, according to the researchers. Tue, 29 Nov 2022 13:44:05 EST //www.koonmotors.com/releases/2022/11/221129134405.htm //www.koonmotors.com/releases/2022/11/221128101233.htm Research has revealed vitamin K1 can help reduce the risk of fractures in older populations -- especially hip fractures. Mon, 28 Nov 2022 10:12:33 EST //www.koonmotors.com/releases/2022/11/221128101233.htm //www.koonmotors.com/releases/2022/11/221128100852.htm Increasing intake of protein and drinking regular cups of tea or coffee is a way women could reduce their risk of suffering a hip fracture, according to new research. Food scientists have found that for women, a 25g a day increase in protein was associated with, on average, a 14% reduction in their risk of hip fracture. In a surprise twist, they also discovered that every additional cup of tea or coffee they drank was linked with a 4% reduction in risk. Mon, 28 Nov 2022 10:08:52 EST //www.koonmotors.com/releases/2022/11/221128100852.htm //www.koonmotors.com/releases/2022/11/221122152749.htm Adolescence is a time of significant skeletal development. In a new report, researchers showed that long-term use of minocycline, an antibiotic used for the systemic treatment of adolescent acne, disrupts the normal gut microbiome, leading to poor bone maturation. Surprisingly, these effects were caused by a change in the gut microbiome, leading to an altered profile of bile acids -- molecules that aid digestion and communicate with many organs -- that suppressed the activity of bone-forming cells called osteoblasts, even after treatment stopped. Tue, 22 Nov 2022 15:27:49 EST //www.koonmotors.com/releases/2022/11/221122152749.htm //www.koonmotors.com/releases/2022/11/221115114019.htm Scientists have made bone marrow 'organoids' that capture the key features of human bone marrow. Tue, 15 Nov 2022 11:40:19 EST //www.koonmotors.com/releases/2022/11/221115114019.htm //www.koonmotors.com/releases/2022/11/221114190554.htm Patients with advanced ankle osteoarthritis who undergo surgery see equally good outcomes from the two main surgical treatments for osteoarthritis, a new study has shown. Mon, 14 Nov 2022 19:05:54 EST //www.koonmotors.com/releases/2022/11/221114190554.htm //www.koonmotors.com/releases/2022/11/221109124400.htm An innovative technology has been developed to enable bone regeneration to correct large bone defects by means of a special hydrogel. Following successful tests in an animal model, the researchers now plan to move forward to clinical trials. Wed, 09 Nov 2022 12:44:00 EST //www.koonmotors.com/releases/2022/11/221109124400.htm //www.koonmotors.com/releases/2022/11/221104113501.htm New research shows how click chemistry can be used to more efficiently deliver drugs to treat tumors in large dogs with bone cancer -- a process that had previously only been successful in small mice. Fri, 04 Nov 2022 11:35:01 EDT //www.koonmotors.com/releases/2022/11/221104113501.htm //www.koonmotors.com/releases/2022/11/221103120044.htm Adult cancer survivors, particularly those diagnosed within five years and/or have a history of chemotherapy, have an increased risk for bone fractures, specifically pelvic and vertebral fractures, compared to older adults without cancer, according to a new large study. Thu, 03 Nov 2022 12:00:44 EDT //www.koonmotors.com/releases/2022/11/221103120044.htm //www.koonmotors.com/releases/2022/11/221101151932.htm Reproduction permanently alters females' bones in ways not previously known, a team of anthropologists has found. Its discovery, based on an analysis of primates, sheds new light on how giving birth can permanently change the body. Tue, 01 Nov 2022 15:19:32 EDT //www.koonmotors.com/releases/2022/11/221101151932.htm //www.koonmotors.com/releases/2022/10/221019171912.htm In medieval Norway, high status individuals tended to be taller and to have stronger bones, possibly as a result of a favorable lifestyle, according to a new study. Wed, 19 Oct 2022 17:19:12 EDT //www.koonmotors.com/releases/2022/10/221019171912.htm //www.koonmotors.com/releases/2022/10/221013114748.htm Each year, 700,000 people die due to antibiotic resistance. A growing global population unfortunately generates a growing resistance to established antibiotic treatments -- a threat that has been met with insufficient funding and dwindling inspiration, as commercial incentives for developing new antibiotics have fallen. A new study addresses this growing problem in antibiotic development using a novel, interdisciplinary approach to construct a robust, computer-program-generated library of antibiotics and to identify an effective antibiotic for targeted use in a bone cement matrix. Thu, 13 Oct 2022 11:47:48 EDT //www.koonmotors.com/releases/2022/10/221013114748.htm //www.koonmotors.com/releases/2022/10/221011183910.htm New research found that young athletes who participate in multidirectional sports, instead of specializing in something like running or cycling, can build stronger bones that are less prone to injury as adults. Tue, 11 Oct 2022 18:39:10 EDT //www.koonmotors.com/releases/2022/10/221011183910.htm //www.koonmotors.com/releases/2022/10/221010115322.htm Considering underlying health issues more comprehensively when a patient has a fracture could better identify those at higher risk of poor health outcomes. Mon, 10 Oct 2022 11:53:22 EDT //www.koonmotors.com/releases/2022/10/221010115322.htm //www.koonmotors.com/releases/2022/10/221007085626.htm More than one million U.S. children fractured a bone while riding a bicycle over the past 20 years, and most of them were boys between ages 10 to 15 years old, according to new research. Fri, 07 Oct 2022 08:56:26 EDT //www.koonmotors.com/releases/2022/10/221007085626.htm //www.koonmotors.com/releases/2022/10/221003132758.htm A research finding in mice that the drug gabapentin improved rehab compliance after spinal cord injury led scientists to a related, unexpected discovery: Injured mice that didn't receive gabapentin and declined to exercise by themselves were willing to hop on the treadmill when presented with a group rehab option. Mon, 03 Oct 2022 13:27:58 EDT //www.koonmotors.com/releases/2022/10/221003132758.htm //www.koonmotors.com/releases/2022/09/220920145435.htm 在一项新的研究中,研究人员表明,每周治疗ments with an epigenetic activator can aid the regrowth of sensory and motor neurons in the spinal cord when given to mice 12 weeks after severe injury. Tue, 20 Sep 2022 14:54:35 EDT //www.koonmotors.com/releases/2022/09/220920145435.htm //www.koonmotors.com/releases/2022/09/220920103425.htm Scientists have shown that high-fat diets can cause rapid changes in the bone marrow of mice, driving the production of inflammatory immune cells, according to new findings. Tue, 20 Sep 2022 10:34:25 EDT //www.koonmotors.com/releases/2022/09/220920103425.htm //www.koonmotors.com/releases/2022/09/220913110416.htm Researchers have developed a novel screening method to identify a drug that mimics the effects of exercise on muscle and bone. Locamidazole (LAMZ) improved muscle width and function and promoted bone formation while reducing bone resorption. LAMZ serves as a potential therapy for the treatment of locomotor diseases, such as sarcopenia and osteoporosis. Tue, 13 Sep 2022 11:04:16 EDT //www.koonmotors.com/releases/2022/09/220913110416.htm //www.koonmotors.com/releases/2022/09/220907105451.htm A new study in mice found that hypertension may be linked to significant bone loss. Bone quality in young mice with high blood pressure was similar to the bones of older mice without high blood pressure, suggesting that the effects of hypertension on bone quality, which includes strength, may mimic that of aging. The researchers suggest early detection and treatment of high blood pressure may help to deter loss of bone quality as people age. Wed, 07 Sep 2022 10:54:51 EDT //www.koonmotors.com/releases/2022/09/220907105451.htm //www.koonmotors.com/releases/2022/09/220906102025.htm New CT technology paired with artificial intelligence (AI)-based noise reduction offers superior detection of bone disease associated with multiple myeloma at lower radiation doses than conventional CT, according to a new study. Tue, 06 Sep 2022 10:20:25 EDT //www.koonmotors.com/releases/2022/09/220906102025.htm